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題名 | 褪黑激素:新提出的抗癌荷爾蒙=Melatonin: A newly Proposed Anti-Cancer Hormone |
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作者 | 季匡華; 王惠暢; 林賢岳; 羅敏菁; 梁麗麗; 賴允亮; Chi, K. H.; Wang, H. C.; Lin, S. Y.; Lo, M. C.; Liang, L. L.; Lai, Y. L.; |
期刊 | 放射治療與腫瘤學 |
出版日期 | 19970900 |
卷期 | 4:3 1997.09[民86.09] |
頁次 | 頁229-236 |
分類號 | 418.27 |
語文 | chi |
關鍵詞 | 褪黑激素; 抗腫瘤劑; 荷爾蒙; Melatonin; Anti-cancer agent; Hormone; |
中文摘要 | 褪黑激素,由松果體分泌的荷爾蒙, 一向被用於調整時差與改善睡眠,雖然在抗 老化效果上被媒體過度吹噓,尚無法被列為指示用藥,但卻有直接、間接的實驗證據顯示褪 黑激素具有直接調節生長荷爾蒙的功能,並有很強的抗氧化及免疫增強力,可減少及預防癌 病的發生或惡化。臨床發現很多癌病患者都有褪黑激素分泌不正常的現象,在補充褪黑激素 後,可觀察到腫瘤抑制作用,病患的精神狀況也獲得改善。 與 Tamoxifen 或介白素二號合 併治療,除有相輔相成的效果之外,更可降低治療的副作用。本文做了文獻溯閱,並對其機 轉做些描述,目的是提醒醫師正視褪黑激素在癌病治療上可能的效果,不要因為坊間的濫用 而忽略它真正的價值。 |
英文摘要 | Melatonin, an over-exaggerated anti-aging hormone used widely around the world for improving sleep quality, has now shown great potential potential in fighting against cancers. Many laboratory and clinical evidences support its oncostatic action, anti-oxidization effect and immune enhancement ability. Cancer patients have altered rhythm of melatonin secretion as compared with healthy people. Clinical trials provide evidences of improving quality of life, increase disease free survival rates and overall survival rates by supplement with melatonin in pharmacological dose. Melatonin can reduce the toxicity from chemotherapy and immunotherapy. It has synergistic effect when combines with Interlukin -2 or tamoxifen. Melatonin may be a newly proposed anti-cancer hormonl for anti-cancer therapy. It should not be overlooked. |
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