頁籤選單縮合
題 名 | Hemodynamic Effects of Chronic Tetrandrine Treatment in Sprague-Dawley Rats |
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作 者 | Huang,Yi-tsau; Cheng,Yuh-ren; Lin,Han-chieh; Chen,Chieh-fu; Hong,Chuang-ye; | 書刊名 | 中國生理學雜誌 |
卷 期 | 40:3 1997.09[民86.09] |
頁 次 | 頁175-178 |
分類號 | 361.1 |
關鍵詞 | Tetrandrine; Radioactive microsphere method; Calcium channel antagonist; |
語 文 | 英文(English) |
中文摘要 | Tetrandrine is a calcium channel antagonist with reported anti-hypertensive effect. The present study aimed to investigate the hemodynamic effects of chronic tetrandrine treatment on normotensive Sprague-Dawley rats. Animals were allocated into one of the two groups:tetrandrine group and vehicle group. Tetrandrine (20 mg/kg) or vehicle was administered by gavage every 12 hours for consecutive 8 days. After 8 days of tetrandrine treatment, systemic hemodynamics and organ blood flows were measured on the next morning after an overnight fast, using radioactive microsphere method. Mean arterial pressure (96 ± 2 vs. 118 ± 4 mmHg) and systemic vascular resistance (254 ± 35 vs. 369 ± 5 dyn. sec.cm �獺� 10 �� /100g body wt) were significantly decreased in the tetrandine group as compared to the vehicle group. The cardiac index (35.2 ± 2.7 vs. 25.5 ± 0.8 mL/min/100 g body wt) was increased in the tetrandrine group. The portal venous pressure, portal tributary blood flow, portal territory vascular resistance, renal blood flow, renal vascular rsistance, herart rate and body weight were similar between the two groups. In conclusion, long-term treatment of tetrandrine reduced mean arterial pressure and systemic vascular resistance but did not change splanchnic renal hemodynamics in normal rats. |
本系統中英文摘要資訊取自各篇刊載內容。