查詢結果分析
相關文獻
頁籤選單縮合
題 名 | Ovarian Cancers Arising from Endometriosis: A Microenvironmental Biomarker Study Including ER, HNF1ß, p53, PTEN, BAF250a, and COX-2 |
---|---|
作 者 | Lai, Chiung-ru; Hsu, Chih-yi; Chen, Yi-jen; Yen, Ming-shyen; Chao, Kuan-chong; Li, Anna Fen-yau; | 書刊名 | Journal of the Chinese Medical Association |
卷 期 | 76:11 2013.11[民102.11] |
頁 次 | 頁629-634 |
分類號 | 417.25 |
關鍵詞 | Biomarkers; Endometriosis; Ovarian neoplasms; |
語 文 | 英文(English) |
英文摘要 | Background: The microenvironmental biomarkers of different subtypes of ovarian cancers arising from endometriosis have not been studied in Taiwan. Their expression can help in understanding the carcinogenic mechanism. Methods: Our study used immunohistochemistry to compare the expression of estrogen receptor (ER), hepatocyte nuclear factor-1 beta (HNF1ß), p53, phosphatase and tensin homolog (PTEN), BAF250a, and cyclooxygenase-2 (COX-2) among 79 cases of endometriosis-associated ovarian cancers, including 40 (50%) clear cell carcinomas (CCCs), 33 (41%) endometrioid (EM) adenocarcinomas, four (5%) serous carcinomas, one adenosquamous carcinoma, and one adenosarcoma. Results: Positive stainings for ER, HNF1ß, p53, and COX-2 were identified in 34 (43%), 30 (38%), 10 (13%), and 44 (56%) cases. Loss of PTEN and BAF250a were noted in 29 (37%) and 37 (47%) cases. The expression of ER was reversely correlated with that of HNF1ß (rho ¼ 0.417, p < 0.001) and correlated with p53 (rho ¼ 0.284, p ¼ 0.011). ER positivity was commonly identified in EM adenocarcinomas (91%), and rarely in CCCs (8%) and serous carcinoma (0%; p < 0.001). By contrast, HNF1ß expression was frequently noted in CCCs (65%) and serous carcinomas (50%), but less in EM adenocarcinoma (6%; p < 0.001). All staining results were similar between atypical endometriosis glandular epithelium and contiguous malignant parts. Only nine cases showed 10 minor differences (10/474, 2%) in ER, HNF1ß, and BAF250a. For the staining patterns of p53, COX-2, and PTEN, there was no difference between the invasive and precursor parts. Conclusion: Our results supported the suggestion that estrogen-dependent ovarian cancer arising from endometriosis is substantially more associated with EM adenocarcinoma than CCCs. The positive HNF1ß staining was a frequent finding in CCCs, but not in EM adenocarcinoma. The similar staining patterns of atypical endometriosis glandular cells with the invasive parts confirmed their precursor status. |
本系統中英文摘要資訊取自各篇刊載內容。