查詢結果分析
來源資料
相關文獻
- 天然海綿有效成份衍生物BN-063於心肌缺血及再循環時期的保護作用
- Angiotensin-I Converting Enzyme Gene Deletion/Insertion Polymorphism and Myocardial Infarction in Taiwan Chinese
- 植入性心律去顫器(ICD)對患者生活品質之影響及其護理
- 探討川芎有效成份之一tetramethylpyrazine於心肌缺血及再循環時期的保護作用
- Acute Myocardial Injury and Ventricular Arrhythmia in Organophosphate Intoxication--A Case Report
- 尿毒症病人的心室性心律不整
- 心律不整
- Relations of Left Ventricular Hypertrophy and Dysfunction with Arrhythmias in Hypertension
- Effect of amiodarone on coronary reperfusion-induced ventricular arrhythmias in dogs
- 冠狀動脈阻塞再灌流的心室性心律不整
頁籤選單縮合
題 名 | 天然海綿有效成份衍生物BN-063於心肌缺血及再循環時期的保護作用 |
---|---|
作 者 | 顏茂雄; | 書刊名 | 中醫藥年報 |
卷 期 | 15:2 1997.05[民86.05] |
頁 次 | 頁407-449 |
分類號 | 414.5 |
關鍵詞 | 心室性心律不整; 缺血性心臟疾病; Adenosine; Doridosine; |
語 文 | 中文(Chinese) |
中文摘要 | 心室性心律不整 (ventricular arrhythmia) 常是缺血性心臟疾病如:心肌梗 塞致死的重要因素。近年來所究報告顯示,adenosine 可改善心肌缺血所引發之心室性心律 不整,而此抗心律不整作用被認為可能是經由活化 adenosine Al 受體所達成的。 BN-063 (1-cyclopropy1- isoguanosine) 是一新合成之 doridosine 衍生物, doridosine 是天然 海綿 (Tedania digitata) 之主成份,且已知是一種非選擇性 adenosine 受體致效劑。 由 本實驗室初步活體之藥理實驗及本學科陶寶綠教授實驗室之離體受體結合實驗結果已證實, BN-063 為一具選擇性之 adenosine Al 受體致效劑。 因此本所究之實驗目欲以大白鼠左冠 狀動脈結紮及皮下注射 isoprotereno1 (7 mg/kg) 方式誘發心律不整, 藉以探討 BN-063 之抗心律不整作用。 結果顯示左冠狀動脈結紮前給予 BN- 063 可使心肌因缺血所導致之心 律不整延後發生,亦可降低心律不整之發生率及嚴重程度,進而改善心肌梗塞的死亡率。左 冠狀動脈結紮後, 以 BN-063 治療亦可改善缺血所導致之心律不整,降低死亡率。 BN-O63 可使因皮下注射 isoproterenol 而導致之心室纖維顫動回復正常節律,增加存活率。 由以 上結果可知:Adenosine Al 受體致效劑 -BN-063,具顯著的抗心律不整作用, 是一具開發 潛力之抗心律不整新藥。 |
英文摘要 | To assess the efficacy of the newly synthesized selective adenosine Al receptor agonist, BN-063 (1- cyclopropylisoguanosine) , against myocardial reperfusion injury, 31 rats underwent 45 min of left coronary artery occlusion and 1 h of reperfusion. Animals were randomly assigned to four groups: control, I0.5-R0.5, in which BN-063 (0.5 mg/kg, i.v. bolus) was administered during both ischemia and reperfusion, R -0.5 and R-1.0, in which BN-063 was administered only during reperfusion at 0.5 and 1.0 mg/kg, respectively. The area at risk was determined by intravascular injection of blue dye during coronary artery occlusion, which was performed by retightening the ligature at the end of reperfusion, and infarct size was determined by incubation of heart slices in nitro blue tetrazolium chloride. A significant reduction in infarct size, as a percentage of the area at risk, was noted with all three BN-063 treatment groups (control: 63.5 ± 4.0%k I0.5-R0.5: 39.6 ± 3.7%, R-0.5: 37.5 ± 3.5%, R-1.0: 38.1 ± 5.2% ). However, the I0.5-R0.5 group did not shown a more beneficial effect than the other two BN-063-treated groups. In addition, BN-063 exerted a protective effect on the number of ventricular premature contractions associated with reperfusion (control: 906 ± 52, I0.5-R0.5: 325 ± 61, R-0.5: 321- ± 95, R-1.0: 340+46). The results of this study demonstrate that BN-063, through activation of adenosine A1 receptors, exerts antiarrhythmic and anti-infarct effects during myocardial ischemia-reperfusion. Therefore, BN-063 would be useful clinically in the treatment and prevention of acute myocardial infarction. |
本系統中英文摘要資訊取自各篇刊載內容。