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題名 | 結直腸癌患者血液生化值之研究=Blood Biochemistry in Relation to Colorectal Cancer |
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作 者 | 王雪芳; 高美丁; | 書刊名 | 弘光醫專學報 |
卷期 | 29 1997.04[民86.04] |
頁次 | 頁327-338 |
分類號 | 416.245 |
關鍵詞 | 結直腸癌; α[feaf]-巨球蛋白; 總膽固醇; 低密度脂蛋白膽固醇; 高密度脂蛋白膽固醇; Colorectal; α[feaf]-macroglobulin; Cholesterol; LDL; Cholesterol; HDL-cholesterol; |
語文 | 中文(Chinese) |
中文摘要 | 本研究係探討結直腸癌患者血液生化值之研究。於1991年9月至1992年11月止,以台中、彰化地區234名健康成人及台中榮總112名結直腸癌患者為研究對象,血液分析採用免疫電泳法測定血清ぽ�茨�-巨球蛋白(ぽ�茨�-macroglobulin,AMG),以默克公司的ESCLIPE測定血清總蛋白(TP)、總膽固醇(TC)、高密度脂蛋白膽固醇(HDL)、低密度脂蛋白膽固醇(LDL)、及三甘油酯(TG)等五項。由血清生化分析結果中發現AMG、HDL值不論控制性別、年齡與否,均與結直腸癌之發生呈顯著之正相關(p<0.05)。另於邏吉斯諦逐步迴歸分析(logisetic stepwise regression)中在控制性別、年齡之後血清中TC、LDL與結直腸癌之發生具有顯著之正相關(F=0.0201,P<0.05);AMG呈顯著之負相關(F=10.4739,<0.05)。由以上結果得知,結直腸癌病人血清中AMG、HDL值降低,而TC與LDL均有升高之現象,但此結果與結直腸癌發生之因果關係仍有待一步的探討。 |
英文摘要 | The purpose of this research is to explore the relationship between cancer and ぽ�茨�-macroglobulin (AMG). From September 1991 until 1992, a control group of the 234 healthy adluts from the Taichung and Changhua area and an experimental group of 112 colorectal patients Taichung Veterans' General Hospital were studied. Blood samples were for dertermining AMG and total protein (TP), trigly cerid (TG) cholesteral (TC), lower density lipid cholesterol (LDL), high density lipid cholesterol(HDL). By means of the blood chemistry, the colorectal patients Both AMG and HDL levels were cholesterol and LDL levels were significantly lower (p<0.05) were shown to be higher TC, LDL than the healthy adult; while the healthy adults' levels of AMG and HDL were higher than colorectal patients found to be significantly higher in the healthy adults than in the colorectal patients (P<0.05); while From the result of logistic stepwise regression, Both AMG and HDL levels were shown to be negatively corrlated to the occurrence of colorectal cancer despite those difference of sex and age; while the chloesterol and LDL levels were shown to be negatively correlated to the occurrence of colorectal cancer despite those difference of sex and age; while the chloesterol and LDL levels were shown to be positively correlated to the occurence colorectal cancer. These data suggest that a AMG and regular blood sample examinations are helpful in the prevention and detection of colorectal cancer. |
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