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題名 | Toxicity of a Single Oral Dose of N-Ethylphenylacetamide in Rats= |
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作者 | 林文川; 劉偉文; 鄭庚生; 施浤漳; 高吉鳳; 許朝添; 郭盛助; Lin, Wen-chuan; Liu, Wei-wen; Cheng, Ken-sheng; Shih, Hung-chang; Kuo, Chi-feng; Hsu, Chao-tien; Kuo, Sheng-chu; |
期刊 | 中華藥學雜誌 |
出版日期 | 19970600 |
卷期 | 49:3 1997.06[民86.06] |
頁次 | 頁135-144 |
分類號 | 418.1 |
語文 | eng |
關鍵詞 | N-ethylphenylacetamide; Single dose toxicity; Rat; |
英文摘要 | The single dose toxicity of N-ethylphenylacetamide(EPA) was studied in rats. The lethal dose (LD�t)and 95% confidence limits of EPA in mg per kg body weight were 822.1 (632.8-1068.1)and 756 (583.9-985.6)by oral administration in male and female rats, respectively. EPA at 400 mg/kg and 800 mg/kg, corresponding to the 1/2 LD�tnd the LD�t respectively, significantly increased the level of blood glucose in both male and female rats. Significantly decreased serum magnesium was observed in both male and female rats given a lethal oral dose of EPA. |
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