頁籤選單縮合
| 題 名 | Effect of N-Phenylacetyl L-Amino Acids on the Differentiation of HL-60 Cells |
|---|---|
| 作 者 | 陳惠明; 許敏聖; 黃麗嬌; 鍾景光; 陳憲煜; 龍鳳娣; 洪啟賦; 廖明徵; 郭盛助; | 書刊名 | 中華藥學雜誌 |
| 卷 期 | 53:3 2001.06[民90.06] |
| 頁 次 | 頁157-167 |
| 分類號 | 418.1 |
| 關鍵詞 | Anti-proliferation activity; Cell differentiation; Phenylacetylamino acids; Structure-activity relationships; |
| 語 文 | 英文(English) |
| 英文摘要 | A series of derivatives of phenylacetic acid and amino acids were prepared and tested against HL-60 cells for their differentiation and antiproliferation activities. Most of the amino acid derivatives were more potent than phenylacetic acid (PAA) in inducing cell differentiation. Among them, N-phenylacetyl L-phenylalanine (22) was the most potent, whereas N-phenylacetyl L-isoleucine (19) and N-phenylacetyl L-tryptophan (23) synergistically potentiated with retinoic acid to induce cell differentiation. On the other hand, N-phenylacetyl L-valine (17), N-phenylacetyl L-leucine (18) and 23 not only induced differentiation, but also promoted cell proliferation. Our results indicate that these compounds are effective cell differentiation agents with low toxicity. |
本系統中英文摘要資訊取自各篇刊載內容。