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題名 | Nasopharyngeal Carcinoma in Bunun Tribe of Taiwan=鼻咽癌在臺灣布農族原住民 |
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作者 | 蕭正光; 楊光明; 高全良; 楊炳炘; 尤瑞鴻; 張慈桂; 陳培榕; | 書刊名 | 慈濟醫學 |
卷期 | 9:1 1997.03[民86.03] |
頁次 | 頁1-9 |
分類號 | 416.879 |
關鍵詞 | 鼻咽癌; 人類白血球抗原; EBV-早期抗原特異抗體; 布農族; Nasopharyngeal carcinoma; HLA; Anti-EBV-EA antibody; Bunun; |
語文 | 英文(English) |
英文摘要 | 連續3位布農族女性被慈濟綜合醫院診斷出罹患鼻咽癌,此一事件引起我們臨床警 覺以及進一步流行病學調查的興趣。由衛生署癌症登記資料庫之資料計算布農族人之鼻咽癌 死亡率為 14/10,發生率為 16/10。年齡調整後,SMR 顯示布農族之鼻咽癌死亡率較臺灣地 區高 5.04 倍,SIR 顯示布農族之發生率較東臺灣地區高 4.19 倍。 13 位布農族鼻咽癌盛 行病例及 56 位非親屬對照組加入本病例對照研究。 HLA-A2 和鼻咽癌之對比值為 1.7(0.5-5.7), 而 HLA-All 和鼻咽癌之對比值對 0.3 (0.1-2.6),雖然並未達到統計顯著 意義,但和其他中國之 HLA 與鼻咽癌相關性之研究結果相當一致。 HLA-B46 和鼻咽癌之對 比值為 1.8(0.1-45.7),HLA-B55 和鼻咽癌之對比值為 2.4(0.7-8.3), 並未達統計顯著意 義,同時也和其他之中國人 HLA 和鼻咽癌研究結果不一致。 鼻咽癌病例之抗 EBV-EA 抗體 較對照為高,但抗體效價在布農族及漢族並無差異。本研究發現鼻咽癌在布農族有高危險的 聚集現象,而其與 HLA 及 EBV 之相關性似也存在於此文化及地理分布獨特之種族。 e comparisons across several studies in Chinese population showed a pattern of consistency. NPC patients also had a higher frequency of B46 and B55 than controls with odds ratios of 1.8(95% CI:0.1-45.7) and 2.4(95% CI:0.7-8.3), respectively. Again, these associations between HLA-B46, B55 and NPC casese were not statistically significant. However, when comparing with two other studies, the association between the HLA-B46, B55 antigens and NPC cases were inconsistent. The serologic data shows the NPC patients had higher anti-EBV-EA antibodies than controls. There was no significant difference of antibody titer between Bunun and Chinese Hans. We concluded that NPC cases occurred in a clustered manner in Bunun. the association of HLA and EBV with NPC also appears to exist in this culturally and geographically unique population.(Tzu Chi Med J 1997; 9: 1-9) |
本系統之摘要資訊系依該期刊論文摘要之資訊為主。