頁籤選單縮合
題 名 | The Clinical Significance of Assay Serum Collagen IV 7S Collagen in Patients with Hepatitis B-Related Liver Disease=在不同肝病中(乙型肝炎相關)測定血清7S第4型膠原的臨床意義 |
---|---|
作 者 | 唐鴻舜; 胡幼圃; 趙有誠; 楊東和; 胡德民; | 書刊名 | 醫學研究 |
卷 期 | 18:5 1998.03[民87.03] |
頁 次 | 頁306-315 |
分類號 | 414.81 |
關鍵詞 | 第4型膠原; 7S膠原; 乙型肝炎肝病; 半乳醣排除能力; Child-pugh值; Child-pugh score; Galactose elimination capacity; Hepatitis B-related liver disease; Type Ⅳ collagen; 7S collagen; |
語 文 | 英文(English) |
中文摘要 | 慢性肝炎的疾病史,纖維化,甚至肝硬化的進行一直為學者所重視,為了評估血清7S第4型膠原質(7S-lV)在不同肝病的臨床意義,我們作了如下回溯性研究。 選擇20位健康者為對照組,176位乙型肝炎所造成不同肝病,包括:23位急性肝炎,75位慢性肝炎及78位肝硬化,慢性肝炎及肝硬化均經組織學證實或臨床上有腹水及凝血因素不良不適切片者。血清中7S-IV的測定所使用是Nippon DPC所出品Collagen lV-7S double antibody RIA Kit。所用統計為Student's test ANOVA、LSD及Iinear regression。 血清中7S-IV在健康組,急性肝炎,慢性肝炎及肝硬化組分別為3.41 ± 0.62、6.23 ± 3.47、7.1 ± 5.34及14.71 ± 8.l9 ng/ml。其中慢性肝炎組與正常組p<0.05,而肝硬化組不論與健康組,急、慢性肝炎組均有意義差別p<0.001。7S-IV與ALT值在急、慢性肝炎均沒有相關性,肝硬化組中則p<0.01。肝硬化組中7S-IV與白蛋白p<0.001,與球蛋白值p<0.05,均有關聯性。63位肝硬化者亦做了半乳醣排除能力(GEC)比較GEC與7S-IV p<0.1,而GEC值與Child-Pugh值成線性關係p<0.001,7S-IV與Child-Pugh值p<0.01。 此結果顯示測量血清中7S-IV,可做為評估肝病變程度,而與急性肝細胞破壞無關,雖然與白蛋白及Child-Pugh值有關,但對評估肝硬化預後不能與GEC相此。 |
英文摘要 | Type IV collagen (IV-C) is one of the main component of basement membrane. The purpose of this study was to assess the clinical significance of assay serum IV-7S (7S collagen) in patients with hepatitis B related liver disease. Compared with a prognostic value of the Child-Pugh's score, and the Galactose elimination capacity (GEC) test. Serum collagen IV-75 (7S collagen) was measured in 176 patients with hepatitis B-related liver disease and 20 healthy controls. 7S collagen was determined with a radioimmunoassay kit purchased from Nippon DPC corporation (Tokyo, Japan). Galactose elimination capacity (GEC) was calculated according to Tysgstrup's equation. The serum concentrations of 7S collagen (mean ±SD) were 3.41 ±0.62 ng/ml in controls, 6.23 ±3.47 ng/ml in acute hepatitis (AH), 7.1 ±5.34 ng/ml in chronic hepatitis (CH) and 14.71 ±8.l9ng/ml in liver cirrhosis (LC). In CH, 7S collagen concentration was slightly increased than that in the control. In LC, 7S collagen concentration was markedly increased than that in the control, AH and CH. 7S Collagen did not correlate with serum ALT levels in AH and CH but there have been relationships between serum ALT levels and 7S collagen concentration in patients with LC. In patients with LC, the serum concentrations of 7S collagen was significantly correlated with the serum levels of albumin and compared with a Child-Pugh score (pcO.01), but Galactose elimination capacity (GEC) values had a more significant relationship compared with the Child-Pugh score (p<0.OO1). These data suggested that the serum concentration of 7S collagen could be useful for evaluation of the disease process of hepatitis B-related liver disease but the prognostic value of the GEC was by far superior to the serum concentration of 7S collagen. |
本系統中英文摘要資訊取自各篇刊載內容。