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頁籤選單縮合
題名 | Lack of NK Cells and Related Cytokines in Pleural Effusion=肋膜腔積液內之自然毒殺細胞與相關細胞激素有減低之現象 |
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作者 | 陳育民; 彭汪嘉康; 楊文光; 洪宜玫; 林文昌; 郭英調; 彭瑞鵬; | 書刊名 | 中華醫學雜誌 |
卷期 | 58:3 1996.09[民85.09] |
頁次 | 頁156-162 |
分類號 | 415.432 |
關鍵詞 | 第十二介白質; 第四介白質; 自然毒殺細胞; 肋膜腔積液; Interleukin-4; Interleukin-12; Natural killer cell; Pleural effusion; |
語文 | 英文(English) |
中文摘要 | 背景 以前的學者曾經發現惡性肋膜腔積液內所含的自然毒殺細胞的 量較少,而且活力較低。至於肋膜腔積液內與自然毒殺細胞相關的細胞激素則 未有文獻探討過。 方法 分析有肋膜病變病患的血液與肋膜積液淋巴球類別,並測量血液與肋膜 積液內的第一、第四,與第十二介白質的含量。 結果 不同原因的肋膜病變均可見到肋膜腔積液內的T幫助型淋巴球比血液內 比率為高。B型淋巴球則無明顯比例上的變化。大部份患者的血液與肋膜腔積 液均測不到第四介白質的存在。少數患者可測到有第一介白質存在,而濃度以 膿胸的積液為最高。絕大部份的肋膜腔積液內自然毒殺細胞比率均比血液明顯 減少。患者的肋膜腔積液與血液也多數測不到第十二介白質的存在。唯一可測 到含有第十二介白質的肋膜腔積液是結核引起的肋膜炎。 結論 許多原因引起的肋膜腔積液所含的T幫助型淋巴球比率比血液所含的為 高,而自然毒殺細胞則是比血液所含的比率為低。雖然本實驗的病例數並非很 多,但是在惡性肋膜腔積液的病患,或許可利用外加第十二介白質來增加吸引 自然毒殺細胞到肋膜腔內,並改善自然毒殺細胞的功能,以克服惡性肋膜腔內 較低的自然毒殺細胞含量與較少的十二介白質。有關這方面的進一步實驗是必 須的。 |
英文摘要 | Background. Relatively low number and activity of natural-killer (NK) cells have been reported in malignant pleural effusions. However, there has been no report on NK cells related cytokines. Methods. Lymphocyte subpopulations were studied in 30 cases of pleural effusion with various etiologies, along with peripheral blood, by using flow cytometry. The related cytokine levels in peripheral blood and pleural fluid, including IL-l alpha, IL-4 and IL-12, were also analyzed with ELISA assays. Results. The results showed significant increase of T-helper cell subpopulation in pleural effusion of various etiologies. No obvious change of B-lymphocyte subpopulation between peripheral blood and pleural effusion was found. IL-4 was undetectable in both peripheral blood and pleural fluid in most cases. IL-l alpha was detectable in some cases and the level was highest in pleural fluid of empyema. Decreased NK cells were found in most cases of pleural effusion and accompanied by undetectable IL-12 both in pleural fluid and peripheral blood. The only one case with detectable IL-12 concentration in pleural fluid was the one with tuberculous pleurisy. Conclusions. Increased T-helper cell subpopulation and decreased NK cell subpopulation were found in pleural effusion of various etiologies. In spite of the small series of our patients, the decrease of NK cell subpopulation and the undetectable IL-12 concentration in pleural effusion deserves further investigations. |
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