頁籤選單縮合
題 名 | Effects of Precollicular Decerebration on the Vasomotor and Sympathetic Nerve Responses to Locus Coeruleus Stimulation |
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作 者 | Chai,C. Y.; Chen,S. Y.; Wang,S. D.; Liu,J. C.; Kuo,J. S.; | 書刊名 | 中國生理學雜誌 |
卷 期 | 39:2 1996.06[民85.06] |
頁 次 | 頁95-104 |
分類號 | 361.1 |
關鍵詞 | Precollicular decerebration; Pressor and depressor responses; Renal and vertebral nerve activities; Pons; Medulla; Locus coeruleus; Parabrachial nu; |
語 文 | 英文(English) |
英文摘要 | In 25 cats under intraperitoneal α-chloralose (40 mg/kg) and urethane (400 mg/kg) anesthesia, cardiovascular reactive sites of locus coeruleun (LC) were stimulated by rectangular pulses (0.5 ms, 80 Hz, 100 to 200 μA) and/or by microinjection of sodium glutamate (Glu, 0.25 M, 70-150 nl). Changes of systemic arterial blood pressure (SAP) and sympathetic vertebral (VNA) and renal (RNA) nerve activities following stimulations were analyzed and, furthermore, SAP responses were compared before and after precollicular decerebration (PD). Microinjeciton of Glu in this region of ten produced a moderate increase and less often decreases SAP. Depressor pints were located dorsal to the sites eliciting pressor response. In the majority of LC stimulations (69%) VNA increased along with the increase of SAP, while the RNA decreases. In a few stimulations marked increase in VNA and decrease in RNA occurred with little change in SAP. PD itself produced various degrees of a temporary (lasted for 5 to 15 min) decrease in SAP from 40 to 100 mmHg. Following PD, three types of change in the LC induced SAP responses were observed in a decreasing order, i.e., the responses wre slightly reduced or slightly augmented, or the LC induced depressor responses were converted to a pressor one. Findings of the present study showed that neural mechanism in LC responsible for the changes of SAP and sympathetic nerve activities may exist in a topographic organization. LC is different from the gigantocellular temental field (FTG) located in the same rostral pons. The marked pressor responses elicited by activation of the FTG depend entirely on the rostral brain structure, while LC is not. Some brain structures rostral to superior colliculi may exert both inhibitory and excitatory influences over LC in cardiovascular integration. |
本系統中英文摘要資訊取自各篇刊載內容。