頁籤選單縮合
題 名 | Rapid Correction of Metabolic Acidosis: Change of Serum Osteocalcin Level in Chronic Renal Failure=快速矯正代謝性酸中毒對慢性腎衰竭血中骨鈣素之影響 |
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作 者 | 余福九; 朱柏齡; 曾素珊; 盧國城; | 書刊名 | 中華民國腎臟醫學會雜誌 |
卷 期 | 8:4 1994.12[民83.12] |
頁 次 | 頁225-231 |
分類號 | 415.815 |
關鍵詞 | Metabolic acidosis; Osteocalcin; Chronic renal failure; |
語 文 | 英文(English) |
中文摘要 | 代謝性酸中毒會抑制造骨細胞的功能與刺激噬骨細胞的功能。本文報告在 18 位尚未接受過任何透析治療的慢性腎衰竭患者,經由連續靜脈注射重碳酸氫鈉矯正其代謝性酸中毒後,測定血中骨鈣素及鹼性磷酸酉每濃度,發現血中骨鈣素有明顯增加(p <0.05),鹼性磷酸酉每有明顯減少 (p<0.001) 的現象。藉此種實快速矯正代謝性酸中毒對於慢性腎衰竭患者,可以改善造骨細胞的功能,並維持身體穩定的酸鹼平衡狀態。 |
英文摘要 | Metabolic acidosis induces a combination of inhibited osteoblastic and stimulated osteoclastic activity. To determine the role of alkali therapy in osteoblast function in chronic renal failure, serum osteocalcin and alkaline phosphatase were assessed before and after bicarbonate infusion. Eighteen patients with mild to moderate metabolic acidosis, none of whom had yet received dialysis therapy, were enrolled in this study.Metabolic acidosis was corrected by continuous bicarbonate infusion while plasma ionized calcium was monitored at 5-minute intervals and held at preinfusion level by calcium solution infusion during the entire procedure. The study was ended when the plasma bicarbonate was approximately 24 mmol/l or pH was around 7.4 and plasma ionized calcium was clamped at preinfusion level with only a 0.01 mmol / 1 fluctuation.The levels of plasma pH (7.31 ± 0.04 vs 7.40 ± 0.03, p < 0.001), bicarbonate (18.46 ± 2.49 vs 23.66 ± 2.72 mmol / 1, p < 0.001), sodium (141.14±4.98 vs 143.06±3.28 mmol/l, p<0.05), serum total calcium (2.013± 0.235 vs 2.120 ± 0.237 mmol / 1, p < 0.00 1), and osteocalcin (15.61 ± 6.45 vs 18.79±6.71jug/l, p < 0.05) increased significantly while the serum concentrations of alkaline phosphatase and albumin decreased significantly after bicarbonate infusion (2.709:i:1.361 vs 2.587± 1.340,ukat/l, p<0.001 and 32.7±5.8 vs 31.6±5.7 g/l, p<0.001 respectively). The serum inorganic phosphorus levels showed no significant difference before and after bicarbonate infusion. These results demonstrate that rapid correction of metabolic acidosis improves osteoblast function, and may probably underline the importance of maintaining normal acid-base homeostasis in chronic renal failure. |
本系統中英文摘要資訊取自各篇刊載內容。