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題 名 | Midtrimester Human Chorionic Gonadotropin Levels: Normal Reference Values in Chinese Pregnant Women=妊娠中期之人類絨毛膜促性腺激素濃度: 國人正常值之建立 |
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作 者 | 徐振傑; 謝燦堂; 羅良明; 宋永魁; | 書刊名 | 長庚醫學 |
卷 期 | 18:3 1995.09[民84.09] |
頁 次 | 頁240-247 |
分類號 | 417.121 |
關鍵詞 | 絨毛膜促性腺激素; 中位數倍數值; 放射免疫分析法; 酵素免疫分析法; Human chorionic gonadotropin; hCG; Multiple of the median; MoM; Radioimmunoassay; RIA; Enzyme immunoassay; EIA; |
語 文 | 英文(English) |
中文摘要 | 人類絨毛膜促性腺激素(Hcg)是由胎盤滋養層細胞所分泌,最早在懷孕第24天即可從母體血中偵測到。目前最常用來偵測Hcg的檢驗方法有放射免疫分析方法(radioimmunoassay)和酵素免疫分析方法(enzyme immunoassay)兩種。為了建立本院中國婦女在懷孕14-22週之hCG濃度中位值,我們隨意收集2711個正常健康、單胞胎的懷孕婦女,其中1705個於懷孕13-24週使用放射性免疫分析法檢驗,1006個於懷孕14-20週使用酵素免疫分析方法檢驗。hCG濃度在不同懷孕週數的分佈圖形與以前文獻類似,濃度在懷孕13週以後迅速下降,懷孕17週以後呈穩定下降。雖然使用放射性免疫分析或酵素免疫分析兩種方法所偵測之hCG濃度,其在各個懷孕週數並無明顯差異,但其中位值測有所不同。如果在懷孕14-20週使用放射免疫分析法時,則有3.7%和17.8%的懷孕婦女其hCG濃度分別低於0.25 MoM和0.5 MoM;而有11%和5.5%的懷孕婦女其濃度分別大於2 MoM和2.5MoM。當使用酵素免疫分析,將有0.7%和9.2%的懷孕婦女其hCG濃度低於0.25 MoM和0.5 MoM;而有8.9%和3.7%大於2 MoM和2.5 MoM。近來hCG被應用於血清篩檢唐氏症,為了得到更準確而滿意的結果,每個實驗室必須收集相當血清數目以建立屬於自己的標準中位值表,並關比較設定標準。本實驗目的在於比較放射免疫分析法和酵素免疫分析法偵測hCG濃度情形,並且希望建立本院中國婦女妊娠中期的標準中位值表。 |
英文摘要 | In order to establish normative median values of maternal serum total human chorionic gonadotropin (hCG) at our own laboratory, 2711 normal sera were collected from uncomplicated, singleton Chinese pregnant women, including 1705 samples measured by radioimmunoassay (RIA) between 13 and 24 weeks’ gestation and 1006 samples measured by enzyme immunoassay (EIA) between 14 and 20 weeks’ gestation. The hCG secretion pattern throughout midtrimester measured by RIA is similar to that of measured by EIA in this study. The maternal serum total (hCG median and mean levels measured by both RIA and EIA have a steep drop initially and then steadily decline from 17 weeks of gestation. The total (hCG levels measured by RIA and EIA showed different normative median values and sistribution. If it was measured by RIA between 14 and 20 week’s gestation, there were 3.7% and 17.8% of pregnancies with serum total hCG levels less than 0.25 multiple of the median (MoM) and 0.5 MoM, respectively, and 11.6% 5.5% among them with serum levels above 2.0 MoM and 2.5 MoM, respectively. When it was measured by EIA, there were 0.7% and 9.2% of pregnancies with serum total hCG levels less than 0.25 MoM and 0.5 MoM, respectively, and 8.9% and 3.7% among them with serum levels above 2.0 MoM and 2.5 MoM, respectively. Accurate and satisfactory interpretation of maternal serum screening for Down syndrome depends on establishment of a well-developed normative median value for each week of gestation. Any laboratory intends to provide hCG for maternal serum screening should have its own reference data by its own immunoassay method. |
本系統中英文摘要資訊取自各篇刊載內容。