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題名 | 先天性糖尿病鼠血漿胃抑素及胰島素對口服葡萄糖刺激之反應 |
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作 者 | 沈賈堯; | 書刊名 | 美和專校學報 |
卷期 | 12 1994.08[民83.08] |
頁次 | 頁23-50 |
分類號 | 415.121 |
關鍵詞 | 先天性糖尿病鼠; 血漿胃抑素; 血漿胰島素; 口服葡萄糖; |
語文 | 中文(Chinese) |
中文摘要 | 本文旨在研究先天性糖尿病鼠於口服葡萄糖刺激後,對胃抑素及胰島 素分泌的影響。BB種系之先天性糖尿病鼠以雌雄分組,各配合BB, Wistar (WS)及Sprague-Dawley(SD)三種系之正常鼠作為對照。所有實驗動物經 右頸靜脈插管手術後,休息一夜;隔天清晨禁食2∼4小時後開始餵實驗 動物口服葡萄糖液(40%,3.2g/kg BW)。口服葡萄糖前10分鐘及口服葡萄糖 後0,10,20,30,45,60及90分鐘各進行每次0.5毫升的採血;其中血糖濃度由葡萄糖 分析儀(YSI,Model 23A)測定,血漿胃抑素及胰島素濃度由放射免疫分析 法測定。先天性糖尿病鼠的血糖濃度於口服葡萄糖前後皆明顯高於正常鼠 ,而血漿胰島素濃度於口服葡萄糖前後則明顯低於正常鼠。雄性糖尿病鼠 血漿胃抑素濃度於口服葡萄糖後20分鐘時高於正常之BB雄鼠,雌性糖尿病 鼠血漿胃抑素濃度於口服葡萄糖後10到20分鐘時高於正常之BB雌鼠;各種系 之正常雄鼠間血漿胃抑素濃度的變化並無明顯差異。SD雌鼠口服葡萄糖後 血漿胃抑素濃度分別高於正常BB雌鼠,WS雌鼠及雌性糖尿病鼠,而WS雌 鼠者又高於正常BB雌鼠。以上實驗結果顯示,BB種系糖尿病鼠血漿胃抑素 對口服葡萄糖刺激之反應比BB種系正常鼠強,而且血漿胃抑素濃度的變化 並具有種系及性別上之差異。 |
英文摘要 | Effects of diabetes on the glucose stimulated secretion of insulin and gastric inhibitory polypetptide (GIP) in rats were investigated. Male and female diabetic BB rats were catheterized via right jugular vein. Normal male and female BB, Wistar (WS) and Sprague-Dawley (SD) rats were used as control. Twenty hours latter, all rats were fasted for 2-4 hours and then ingested with glucose (40%, 3.2 g/kg BW), Blood samples were collected at -10, 0, 10, 20, 30, 45, 60 and 90 minute after oral glucose analyzer. The concentration of plasma GIP and plasma insulin was measured by radioimmunoassay. The concentration of blood glucose was higher and plasma insulin was lower during fast and following oral glucose load in diabetic BB rats than in normal BB, WS and SD rats. Concentration of plasma GIP at 20 minute post-oral glucose was higher (P<0.05) in male diabetic rats than in normal male BB rats and at 10 and 20 minute post-oral glucose was higher (P<0.05) in female diabetic rats than in normal BB rats. In females, concentration of plasma GIP after oral glucose load was higher in SD than in diabetic, normal BB and WS rats, and was also higher in WS than in normal BB rats. The results suggest that (1)GIP secretion is increased in diabetic BB rate when compared with normal BB rats after oral glucose ingestion, (2)the change of plasma GIP concentration is dependent upon sex and species. |
本系統之摘要資訊系依該期刊論文摘要之資訊為主。