頁籤選單縮合
題 名 | SAR Analysis of the Epstein-Barr Virus DNA Polymerase Inhibitors |
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作 者 | 林美珠; 陳瓊雪; 郭悅雄; 邱卓凡; | 書刊名 | 中華藥學雜誌 |
卷 期 | 50:1 1998.02[民87.02] |
頁 次 | 頁13-24 |
分類號 | 418.4 |
關鍵詞 | Antiviral agents; Epstein-barr virus DNA polymerase; EBV-DP; Lignans; Natural products; Parameter-frame-setting; Phenols; Quantitative structure-activity relationship; QSAR; α,β-unsaturated-γ-lactones; |
語 文 | 英文(English) |
英文摘要 | A semiquantitative structure-activity relationship of forty-nine compounds including lignans, phenols and α, β-unsaturated-γ-lactones was analyzed by using a parameter-frame-setting method. Based on the result, a quantitative analysis was performed and a statistically significant correlation was obtained between the inhibitory activities (log 1/IC �t ) of 16 compounds against Epstein-Barr virus DNA polymerase (EBV-DP) and physicochemical parameters (CMR, Clog P and μ ). The structural requirements for the optimum activity against EBV-DP of these groups of compounds were identified. These findings provide physicochemical bases for further structural modification and optimization of the lead natural products. |
本系統中英文摘要資訊取自各篇刊載內容。