頁籤選單縮合
題名 | 中藥濃縮製劑製程中微生物污染之探討 |
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作者姓名(中文) | 顧祐瑞; 周令玫; 張秋芳; 劉宜祝; 林哲輝; 溫國慶; | 書刊名 | 藥物食品分析 |
卷期 | 2:1 1994.03[民83.03] |
頁次 | 頁49-62 |
分類號 | 412.36 |
關鍵詞 | Traditional chinese medicine; Concentrated preparation; Microbial contamination; Contamination source; |
語文 | 中文(Chinese) |
英文摘要 | To better understand sources of microbial contamination during manufacturing of traditional concentrated Chinese medicines, examinations of total plate count,coliforms, Bacillus cereus, spore count of bacilli, spore count of Bacillus cereus, Staphylococcus aureus, Salmonella, Proteus, yeasts and molds were made on crude drugs (119 samples), decoctions (20 samples), concentrated decoctions (25 samples), excipients (23 samples), semiproducts (61 samples), products (20 samples), container contact swab tests (104 samples) and settling plate tests (95 samples) from five pharmaceutical factories. They were Sheau-Jiann-Jong-Tang (小建中湯),Hwang- Lian-Jiee-Dwu-Tang (黃連解毒湯), Ger-Gen-Tang (葛根湯), Dah-Ching-Long-Tang (大青龍湯) and Sheau-Chair-Hwu-Tang(小柴胡湯). Results showed that crude drugs such as Ginseng Radix, Glycyrrhizae Radix and Zingiber Rhizoma had serious contamination, while using starch of lactose as excipients showed lesser degree of microbial contamination. Granulation process during pharmaceutical manufacturing was the key source of contamination, as well as affected by using crude drug powder as excipients, or using contaminated tools, containers and/or processing rooms. Based on statistical analysis, there existed significant differences among the five pharmaceutical products and five factories concerning microbial contamination. Container contact swab test indicated that the workers themselves had a high degree of contamination, while settling plate tests showed that the processing rooms producing flying powders had increased risk of contamination. |
本系統之摘要資訊系依該期刊論文摘要之資訊為主。