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題名 | The Correlation Between 24-Hour-Urine Protein And Spot Urine Protein/Creatinine Ratio and The Inconstancy of Daily Urine Protein And Creatinine Excretion=24小時尿蛋白與單次尿蛋白∕尿肌酸酐比值間關係及每日尿蛋白肌酸酐排泄量之非衡定性 |
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作者 | 萬象; 郭泰松; |
期刊 | 慈濟醫學 |
出版日期 | 19920600 |
卷期 | 4:2 1992.06[民81.06] |
頁次 | 頁100-105 |
分類號 | 415.74 |
語文 | eng |
關鍵詞 | 比值; 肌酸酐; 尿肌酸酐; 尿蛋白; 每日; 排泄量; 單次; |
中文摘要 | 24小時尿蛋白之測定,可作為早期腎病之診斷參考,它亦是腎病症候群 的一項重要診斷檢查。肌酸酥廓清率是腎功能的一項重要指數,可作腎病進展之 追蹤。前一檢查項目要收集24小時尿,因此當有病人不便及留尿不準確等問題。 我們試圖以單次小便之蛋白Z肌酸酥比價代替24小時尿蛋白檢查。從100位可行動 之門診病人中收集24小時小便及其當日之隨意單次小便。另一方面,我們從26 位住院且插有尿管病人中連續收集4天24小時小便及於第一天中,分別在早上7 點,II點,下午5點,9點各收集一次單次小便。所有小便標本均迭作蛋白及肌酸 酐測定。結果顯示單次小便蛋白/肌酸酐比值與24小時尿蛋白量有很好的相關 性,門診病人r=0.72,住院病人r=0.75-0.85,全部p<0.01。每日24小時小便肌酸酐、 蛋白排出量及肌酸酐廓清率呈現不穩定(CV>15),機率分別是30.8,65.4及61.5。 總之:隨意單次尿蛋白/肌酸酐比值可作當日24小時尿蛋白的替代表示法,每日尿 蛋白及肌酸酐排泄量及肌酸酐廓清率在一些病人中並非保持平穩狀態(慈濟醫學 1992:4:100-105) |
英文摘要 | Twenty-four-hour wine protein is measured for diagnosis of early renal disease and it is an important diagnostic test of nephrotic syndrome. Creatinine clearance (Ccr) is commonly used as index ofrenal function and used for following the progress of renal function. The daily urine collection is inconvenient and difficult. We tried to evaluate the possibility to use the single voided urine proteWcreatinine (prot/creat) ratio substituting 24 hours urine protein examination. We collected 24 hoursurine and a random single urine on the same day from 100 ambulatory outpatients. In other hand, wealso collected 24 hours urine for 4 days and single urine at 7:00am, 11:00am, 5:00pm and 9:00pmrespectively in the first day from 26 inpatients with urine catheter. Their renal functions are stable. Allthe urine samples were sent for protein and creatinine measurements. The results showed good correlations between prot/creat ratio and 24 hours urine protein (r=0.72 in outpatients; r=0.75-0.85 in inpatients, all p<0.01). The incidences of high variance (CV > 75) in sequential days' 24 hours urinecreatinine and protein excretion, and Ccr are 30.8, 65.4 and 61.5 respectively. In conclusion:random single urine prot/creat ratio may be as an alternative of 24 hours urine protein detection. Thedaily urine protein and creatinine excretion, and Ccr are not so steady in a lot of patients. (Tz'u-ChiMedJ 1992; 4:100-105) |
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