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題名 | 臺灣乳山羊併發感染艾利希體病之臨床病理學變化 |
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作者姓名(中文) | 曾秋隆; 楊忠亮; | 書刊名 | 臺灣畜牧獸醫學會會報 |
卷期 | 58 1991.12[民80.12] |
頁次 | 頁91-99 |
分類號 | 437.58 |
關鍵詞 | 艾利希體病; 乳山羊; 病理學; 感染; 臺灣; 臨床; |
語文 | 中文(Chinese) |
中文摘要 | 一頭兩歲雌性撇能種乳山羊因持續性高燒、厭食、萎靡、產乳量下降、呼吸及 心跳增快、瘤胃蠕動減慢、泡沫性流涎、頸部與下顎部水腫等症狀被送到國立中興大學附設 家畜醫院診治。血檢時患羊有嚴重貧血;白血球減少症,嗜中性球明顯核形左轉,淋巴球減 少症。在血液塗抹片中的嗜中性球與單核球細胞質中存有一個或多個0.3~2μx0.3~0.5μ、 球狀或短桿狀藍紅色的包涵體分佈(賴特氏染色);另在紅血球表面上亦有少數羊附紅血球體 寄生。臨床生化學檢查有高蛋白血症與高織維素原血症。尿液檢查發現有顯著蛋白尿,糖尿 與輕微酮尿。自頸部水腫處與腫大淋巴結做生體檢查卻抽不出液體。屍體解剖發現頸部與下 顎部水腫,頸部淋巴結腫大外,其他各臟器皆正常。並自水腫患部組織做細菌學培養,只分 離出化膿棒狀桿菌(Corynebacterium pyogenes)。組織病理學檢查頸部肌肉有急性炎症反 應,嗜中性球侵潤,其中並存有許多細菌斑塊,滲出液與纖維素等;肌肉呈透明樣退行性變 化,肌肉纖維有明顯損傷;肝小葉有脂肪變性;頸部淋巴結亦有嗜中性球侵潤,小膿?內含 細菌團塊。其他各臟器組織皆正常。發病期間畜主曾以Ampicillin與Sulpyrin治療病羊皆 無療效:病羊在本院住院期間亦曾以抗生素、強心劑與其他藥物加以治療,最後仍不治而死 亡。將病羊的組織接種於犬隻與小白鼠,僅小白鼠接種成功。 |
英文摘要 | A two-year-old sannen nanny goat was sent to our hospital (NCHUVTH) with persistent pyrexia, poor appetite, depression, reducing milk production, increasing respiration and heart beat rates, decreasing rumen peristalsis, foam salivation and edema in chin and neck. In blood examinations: she showed severe anemia; leucopenia, markable neutrophilic shift to left, lymphopenia; 0.3-2μ x 0.3-0.5μx in size, coccoid or rod shape, dark blue color, 1-10 inclusion bodies were distributed in the cytoplasm of neutrophils and monocytes from blood smears; some eperythrozoon also parasited in the host erythrocytes. Hyperproteinemia and hyper-fibrinogenemia were also found; she had severe proteinuria, glycosuria and slight ketonuria No fluid was extracted from the edematous lesions and enlarged lymph nodes by biopsy. In gross findings: edema wasnoted on the cervical and chin muscles; the cerival lymph nodes became swelling. In histopthological findings the cervical muscle-acute inflammation, neutrophils infiltration, bacteria mass, hyaline degeneration, exudates withfibrin, muscle fiber damaged; liver with central lobular fatty changed; cervical lymp h nodesneutrophils infiltration, microabscess and bacteria mass. Corynebacterium pyogenes were isolated from the edema area of neck by anaerobic and aerobic culture. The owner had used ampicillin and sulpyrin to treat all cases. She also treated with antibiotics, anaka and other drugs during admission, but withouthelpless. One dog and eight mice were indivi dually intraperitoneal injection with 5 mal and 0.2 ml infected tissues, only the mice were successful. |
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