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- Human Papillomavirus Detection in Adenocarcinoma and Adenosquamous Carcinoma of the Uterine Cervix in Taiwan
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- Role of Magnetic Resonance Imaging and Apparent Diffusion Coefficient at 3T in Distinguishing between Adenocarcinoma of the Uterine Cervix and Endometrium
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- 子宮頸腺癌
頁籤選單縮合
題 名 | Human Papillomavirus Detection in Adenocarcinoma and Adenosquamous Carcinoma of the Uterine Cervix in Taiwan=臺灣地區子宮頸腺癌及腺鱗狀癌之人類乳突病毒感染偵測 |
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作 者 | 曾暉華; 王志生; 簡婉儀; | 書刊名 | 中華醫學雜誌 |
卷 期 | 57:1 1996.01[民85.01] |
頁 次 | 頁47-53 |
分類號 | 417.2832 |
關鍵詞 | 腺癌; 腺鱗狀癌; 子宮頸腺癌; 人類乳突病毒; 原位雜交; 病毒嵌入; Adenocarcinoma; Adenosquamous carcinoma; Cervical carcinoma; Human papillomavirus; In situ hybridization; Virus integration; |
語 文 | 英文(English) |
中文摘要 | 背景:子宮頸腺癌及腺鱗狀癌與人類乳突病毒(HPV)有關。但HPV與子宮頸腺癌及腺鱗狀癌之組織學亞型之關係卻不清楚。本研究的目的乃是在探討:一、臺灣地區子宮頸腺癌及腺鱗狀癌之HPV流行率。二、HPV與子宮頸腺癌及腺鱗狀癌之組織學亞型,分化程度,及腫瘤分期之關聯。三、HPV於子宮頸腺癌及腺鱗狀癌中扮演之角色。 方法:我們以非放射性原位雜交技術於三十三例子宮頸腺癌及十二例腺鱗狀癌之蠟塊標本,偵測其HPV DNA,首先以FITC連接之廣泛型HPV探針篩檢,再以HPV6/11,16,18,31,33型探針偵測其亞型。 結果:三十三例子宮頸腺癌有十五例(45%)呈HPV陽性。其中有十例(30%)屬HPV18 型,四例(12%)屬HPV16型。於子宮頸腺鱗狀癌,七例含HPV DNA,其中有二例(17%)屬HPV18,三例(25%)屬HPV 16。有一例子宮頸腺癌及二例腺鱗狀癌無法鑑定出其HPV亞型。HPV之狀態與組織學亞型,分化程度,及腫瘤分期無相關聯。所有HPV陽性之子宮頸腺癌均含點狀細胞核信號。於腺鱗狀癌,其信號表現呈異質性。除一例外,所有HPV陽性例,其病毒DNA均嵌入細胞核內。 結論:本研究結果顯示部份臺灣地區子宮頸腺癌及腺鱗狀癌與HPV感染有關。於子宮頸腺癌HPV18型感染佔優勢,此與大部份地區之報告相同。HPV之狀態與組織學亞型,分化程度,及腫瘤分期無相關聯。除一例外,所有HPV陽性例,均含點狀細胞核信號,此被認為病毒DNA已嵌入細胞核內。本結果顯示在子宮頸腺癌及腺鱗狀癌之癌化過程中,HPV可能扮演重要之角色。 |
英文摘要 | Background: The association of human papillomavirus (HPV) with cervical adenocarcinoma (ADC) and adenosquamous carcinoma (ADSC) is well documented. The relationship between HPV and the histopathology of ADC and ADSC is not clearly understood. This study proposed to evaluate: 1. the prevalence of HPV infection in cervical ADC and ADSC in Taiwan; 2. any correlation of HPV and histologic subtypes, grading and tumor staging of ADC and ADSC; 3. the possible role of HPV in cervical ADC and ADSC. Methods: HPV detection was carried out using a non-isotopic in situ hybridization (ISH) technique on paraffin sections of 33 cervical ADC and 12 ADSC. An FITC-labelled probe of wide spectrum HPV was used for screening, and probes of HPV 6/11, 16, 18, 31, 33 were used for typing. Results: Of the 33 cases of cervical adenocarcinoma, 15 (45%) were HPV positive; of these, 10 (30%) were HPV 18, and 4 (12%) were HPV 16. In ADSC, 7 (58%) cases contained HPV DNA, of which HPV 18 was detected in 2 (17%), and type 16 in 3 (25%). Unidentified HPV types were found in one and in two cases of ADC and and ADSC, respectively. There were no significant correlations between HPV status and histologic subtypes, grading and tumor staging. All the HPV-positive ADC contained punctate nuclear HPV signals. In ADSC, the signal pattern was heterogeneous. HPV DNA was integrated in all but one viral positive cases. Conclusions: These results indicate that ADC and ADSC of cervix in Taiwan were associated with HPV infection. HPV 18 was predominant in ADC similar to the reports from most other regions. There was no correlation between HPV and histopathologic findings of ADC and ADSC. The punctate signals suggestive of viral DNA integration were found in all but one HPV positive cases. The result supports the hypothesis that HPV may play an important role in pathogenesis of cervical ADC and ADSC. |
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