頁籤選單縮合
題 名 | Hepatitis B, C and D Viruses and Adult Primary Glomerulonephritis in Taiwan=臺灣B型、C型和D型肝炎與成人原發性腎小球腎炎的關係 |
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作 者 | 陳萬裕; 陳永銘; 洪冠予; 嚴澯鑫; 高全良; 許輝吉; 楊垂勳; | 書刊名 | 中華民國腎臟醫學會雜誌 |
卷 期 | 8:1 1994.03[民83.03] |
頁 次 | 頁16-23 |
分類號 | 415.812 |
關鍵詞 | Hepatitis B; C and D viruses; Adult primary glomerulonephritis; |
語 文 | 英文(English) |
中文摘要 | 台灣是 B 型肝炎盛行區域,許多研究發現 B 型肝炎和兒童膜性腎病變 (membranous ne-phropathy,MN) 有闕 , 至於和成人原發性腎小球腎炎 (primary glpmerulonephritis, 簡稱PGN) 的關係則尚未確立。目前有關 PGN 和 C Z 型肝炎的研究還很少,至於和 D 型肝炎的關係則查諸文獻尚未有專文報告。本報告的主旨在探討 B 型、 C 型和 D 型肝炎病毒與 PGN的關係。 選擇 144 位有組織病理診斷的 PGN 病人和 592 位正常對照組作比較,以放射免疫法 (radioimmunoassay RIA) 測定 B 型核心(anti-HBc),C 型 (anti-HCV) 和 D 型 (anti -Delta) 肝炎病毒抗體的盛行率。結果如下:PGN 病人的 B 型肝炎核心抗體盛行率(62.5%) 比對組的 80.2% 低,而且具統計學上的差異,這可能和後者平均年齡較大 (40 ± 1 VS.44 ± 1,P<0.01) 有關。針對不同年齡族群分析,正常對照組中 B 型和 C 型肝炎抗體的盛行率分佈有隨年齡增加而遞增。 PGN 病人的 C 型 肝炎抗體盛行率 (6.2%) 略高於對照組的 3.8%,但不具統計學上意義的差異。比較各不伺 PGN 病理類型病人的 C 型肝炎抗體盛行率 , 也 沒有發現明顯的差異。在 PGN 病人中,有 4 例 (2.7%) 血清發現 同時呈 anti-HBc 和 anti-HCV 陽性反應,和正常對照組 (21例 ,3.5%) 相比不具統計學上的差異,再次顯示 HBV 及 HCV 和 PGN 之發生無關。至於 D 型肝炎的盛行率在 PGN I44 例中,24 例 (16.0%)HBsAg(+) 病人中及對照組 592 位中 (14.3%)HBsAg(+) 中,則尚未發現同時有 anti-Delta(+) 的病例。結論是:目前在台灣的研究,成人 PGN 病 人和 B 型及 C 型肝炎病毒感染顯示可能無關聯,又至目前此研究在 PGN 病人及對照組人中,尚無有 anti-delta(+) 者。 |
英文摘要 | Taiwan is one of the endemic areas with high prevalence of hepatitis B virus(HBV) infection. The association of HBV infection with membranous nephropathy (MN ) in children has been well studied and recognized. However, the results of the investigations on the association of adult primary glmerulonephritis (PGN) with HBV infection were controversial. To our knowledge, there have been very few data available concerning the relationship between hepatitis C (HCV) infection and PGN, and no data have been reported regarding the association of heaptitis D (HDV) infection with PGN. In this study, the prevalence rates of seropositivity of HBsAg, anti-HBc, anti-HCV and anti-D in adult PGN as well as normal controls were examined. Serum samples obtained from 144 adult PGN and 592 normal controls were investigated. The tests for HBsAg, anti HBc and anti D were studied by radioimmunoassay (Abbott Labs, U.S.A.) and anti-HCV (Abbott HCV EIA Kits) was examined by enzyme immunoassay method. The prevalence rate of anti-HCV(+) was higher in PGN patients (6.2%) than in controls (3.8%), but the difference was not significant. The frequency of anti-HCV(+) as well as anti-HBc(+) in various pathologies of PGN was not significantly different from that of controls. The prevalence rates of both anti-HBc(+) and anti-HCV(+) in PGN patients(2.7%) and controls (3.5%) were not significanty different too. No positive anti-delta in PGN and controls was obtained. In conclusion, no significant association was observed between adult PGN and HBV or HCV infection in Taiwan, and no positive case with anti-delta in PGN and controls was obeserved. |
本系統中英文摘要資訊取自各篇刊載內容。