頁籤選單縮合
題 名 | The Effect of Low-level Laser Therapy on Osteoclast Differentiation: Clinical Implications for Tooth Movement and Bone Density |
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作 者 | Huang, Chun-yi; Le, Huynh Hoai Thuong; Tsai, Hsiao-chi; Tang, Chih-hsin; Yu, Jian-hong; | 書刊名 | Journal of Dental Sciences |
卷 期 | 19:3 2024.07[民113.07] |
頁 次 | 頁1452-1460 |
分類號 | 416.949 |
關鍵詞 | Bone density; Low level laser therapy; Orthodontic tooth movement; Osteoclast cell; |
語 文 | 英文(English) |
DOI | 10.1016/j.jds.2024.03.023 |
英文摘要 | Background/purpose: Osteoclast differentiation is crucial for orchestrating both tooth movement and the maintenance of bone density. Therefore, the current study sought to explore the impact of low-level laser therapy (LLLT) on osteoclast differentiation, functional gene expression, molecular signaling pathways, and orthodontic tooth movement in clinical settings. Materials and methods: The RAW 264.7 cell line served as the precursor for osteoclasts, and these cells underwent irradiation using a 808-nm LLLT. Osteoclast differentiation was assessed through tartrate-resistant acid phosphatase (TRAP) staining. Functional gene expression levels were evaluated using real-time quantitative polymerase chain reaction (RT-qPCR) while signaling molecules were examined through Western blot analysis. In the clinical study, 12 participants were enrolled. Their tooth movement was monitored using a TRIOS desktop scanner. Bone density measurements were conducted using Mimics software, which processed conebeam computed tomography (CBCT) images exported in Digital Imaging and Communications in Medicine (DICOM) format. Results: We found that LLLT effectively promoted receptor activator of nuclear factor-kB ligand (RANKL)-dependent osteoclast differentiation and the expression of osteoclast functional genes, including matrix metallopeptidase 9 (MMP9), nuclear factor of activated T-cells cytoplasmic 1(NFATc1), tartrate-resistant acid phosphatase (TRAP) and cathepsin K (CTSK) in RAW264.7 cells. Clinically, the cumulative tooth movement over 90 days was significantly higher in the laser group than in the control group. Conclusion: Our research demonstrates that LLLT not only significantly promotes osteoclast differentiation but is also a valuable adjunct in orthodontic therapy. |
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