頁籤選單縮合
題名 | Isolation of GLP-1 Enhancing Indolizidine Alkaloids from Boehmeria formosana= |
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作者 | Lu, Ching-yi; Huang, Zheng-ying; Chen, Meng-chin; Liu, Hui-kang; Lee, Shoei-sheng; Chang, Chia-chuan; |
期刊 | Journal of Food and Drug Analysis |
出版日期 | 20231200 |
卷期 | 31:4 2023.12[民112.12] |
頁次 | 頁739-771 |
分類號 | 341.95 |
語文 | eng |
關鍵詞 | α-glucosidase inhibitor; Boehmeria formosana; GLP-1-enhancing ability; Phenanthroindolizidine alkaloids; Secondary metabolites; |
英文摘要 | Boehmeria formosana, with its related species, demonstrates anti-glycemic effect, inhibition of HBV production, anti-cancer activities, etc. Some indolizidine alkaloids from the same genus are bioactive but sensitive to light. To overcome this problem and obtain more phenanthroindolizidine alkaloids, isolation was performed in darkness, yielding 10 new indolizidine alkaloids and 17 known compounds. Among them, seven enhanced glucagon-like receptor 1 (GLP-1) activity at 50 mM, especially 14 and 6 (3.5- and 2.3-fold than the negative control). This procedure yielded bioactive indolizidine alkaloids with novel structures. |
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