頁籤選單縮合
題 名 | Characterization of Young Infants with Fecal Carriage of Multidrug-resistant Escherichia coli in Southern Taiwan |
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作 者 | Lin, Fang-chih; Ng, Victor Wailap; Wang, Hsiao-ping; Hung, Chih-hsin; Chang, Jenn-tzong; Yang, Chih-chieh; Liu, Po-yen; Cheng, Ming-fang; | 書刊名 | Pediatrics and Neonatology |
卷 期 | 65:2 2024.03[民113.03] |
頁 次 | 頁138-144 |
分類號 | 417.517 |
關鍵詞 | Escherichia coli; Extended-spectrum β-lactamase; Multidrug-resistance; ST131; Young infants; |
語 文 | 英文(English) |
DOI | 10.1016/j.pedneo.2023.04.014 |
英文摘要 | Background: The accelerating prevalence of extended-spectrum β-lactamase (ESBL)-producing and multidrug- resistance (MDR) Escherichia coli (E. coli) become a public health challenge worldwide. This study aimed to discuss the prevalence of drug-resistant E. coli colonization and analyze its risk factors and clinical characteristics among young infants in Southern Taiwan. Methods: Stool samples were collected from young infants, aged less than three months, within three days of their hospitalization from September to December 2019 in a tertiary hospital. A questionnaire was designed for parents to complete. E. coli colonies were selected and analyzed for antimicrobial susceptibility. PCR-based multilocus sequence typing was to detect the presence of sequence type ST131 and blaCTX-M genes. Results: Among 100 enrolled infants, 36% had fecal carriage of E. coli isolates, of which twenty nine (80.5%) were MDR, thirteen (36.1%) were ESBL-producing isolates and five (13.8%) and ten (27.7%) were ST131 and strains carrying CTX-M-14 gene, respectively. Compared to non-ST131 and non-CTX-M-14 gene carrier, isolates of ST131 and CTX-M-14 gene carrier showed a significantly higher resistance rate to cefixime, ceftriaxone, and gentamycin, with p value all <0.05. Conclusion: The prevalence of ESBL-producing and MDR E. coli fecal carriage were both high in young infants. The most common sequence type is ST131, of which all are strains carrying CTX-M-14. Further surveillance and investigation to control for the high prevalence of antimicrobial-resistant E. coli fecal carriage among infants in Taiwan are warranted. |
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