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題 名 | Air Pollution Associate with Advanced Hepatic Fibrosis among Patients with Chronic Liver Disease |
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作 者 | Jang, Tyng-yuan; Ho, Chi-chang; Liang, Po-cheng; Wu, Chih-da; Wei, Yu-ju; Tsai, Pei-chien; Hsu, Po-yao; Hsieh, Ming-yen; Lin, Yi-hung; Hsieh, Meng-hsuan; Wang, Chih-wen; Yang, Jeng-fu; Yeh, Ming-lun; Huang, Chung-feng; Chuang, Wan-long; Huang, Jee-fu; Cheng, Ya-yun; Dai, Chia-yen; Chen, Pau-chung; Yu, Ming-lung; | 書刊名 | The Kaohsiung Journal of Medical Sciences |
卷 期 | 40:3 2024.03[民113.03] |
頁 次 | 頁304-314 |
分類號 | 415.53 |
關鍵詞 | Advanced liver fibrosis; Air pollution; MAFLD; Transient elastography; PM₂.₅; |
語 文 | 英文(English) |
DOI | 10.1002/kjm2.12781 |
英文摘要 | We aimed to investigate the association between air pollution and advanced fibrosis among patients with metabolic associated fatty liver disease (MAFLD) and chronic hepatitis B virus (HBV) and hepatitis C virus (HCV) infections. A total of 1376 participants who were seropositive for HBV surface antigen (HBsAg) or antibodies to HCV (anti-HCV) or had abnormal liver function in a community screening program from 2019 to 2021 were enrolled for the assessment of liver fibrosis using transient elastography. Daily estimates of air pollutants (particulate matter ≤2.5 μm in diameter [PM2.5], nitrogen dioxide [NO2], ozone [O3] and benzene) were aggregated into mean estimates for the previous year based on the date of enrolment. Of the 1376 participants, 767 (52.8%) and 187 (13.6) had MAFLD and advanced fibrosis, respectively. A logistic regression analysis revealed that the factors associated with advanced liver fibrosis were HCV viremia (odds ratio [OR], 3.13; 95% confidence interval [CI], 2.05–4.77; p < 0.001), smoking (OR, 1.79; 95% CI, 1.16–2.74; p = 0.01), age (OR, 1.04; 95% CI, 1.02–1.05; p < 0.001) and PM2.5 (OR, 1.10; 95% CI, 1.05–1.16; p < 0.001). Linear regression analysis revealed that LSM was independently correlated with PM2.5 (β: 0.134; 95% CI: 0.025, 0.243; p = 0.02). There was a dose-dependent relationship between different fibrotic stages and the PM2.5 level (the PM2.5 level in patients with fibrotic stages 0, 1–2 and 3–4: 27.9, 28.4, and 29.3 μg/m3, respectively; trend p < 0.001). Exposure to PM2.5, as well as HBV and HCV infections, is associated with advanced liver fibrosis in patients with MAFLD. There was a dose-dependent correlation between PM2.5 levels and the severity of hepatic fibrosis. |
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