頁籤選單縮合
題名 | Chemical Constituents from the Medicinal Herb-derived Fungus Chaetomium globosum Km1226 |
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作 者 | Chang, Chia-hao; Hsiao, George; Wang, Shih-wei; Yen, Juei-yu; Huang, Shu-jung; Chi, Wei-chiung; Lee, Tzong-huei; | 書刊名 | Botanical Studies |
卷期 | 64 2023[民112] |
頁次 | 頁(34)1-(34)9 |
分類號 | 373.8 |
關鍵詞 | Chaetomium globosum; Aureonitol; Mollipilin; Polyketide; Anti-inflammation; Anti-angiogenesis; |
語文 | 英文(English) |
DOI引用網址 | 10.1186/s40529-023-00406-8 |
英文摘要 | Background Endophytic fungi have proven to be a rich source of novel natural products with a wide-array of biological activities and higher levels of structural diversity. Results Chemical investigation on the liquid- and solid-state fermented products of Chaetomium globosum Km1226 isolated from the littoral medicinal herb Atriplex maximowicziana Makino resulted in the isolation of compounds 1–14. Their structures were determined by spectroscopic analysis as three previously undescribed C13-polyketides, namely aureonitol C (1), mollipilins G (2), and H (3), along with eleven known compounds 4–14. Among these, mollipilin A (5) exhibited significant nitric oxide production inhibitory activity in LPS-induced BV-2 microglial cells with an IC50 value of 0.7 ± 0.1 µM, and chaetoglobosin D (10) displayed potent anti-angiogenesis property in human endothelial progenitor cells (EPCs) with an IC50 value of 0.8 ± 0.3 µM. Conclusions Three previously unreported compounds 1–3 were isolated and identified. Mollipilin A (5) and chaetoglobosin D (10) could possibly be developed as anti-inflammatory and anti-angiogenic lead drugs, respectively. |
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