頁籤選單縮合
題名 | The Effects of SARS-CoV-2 Infection on Modulating Innate Immunity and Strategies of Combating Inflammatory Response for COVID-19 Therapy |
---|---|
作 者 | Wang, Yiran; Wu, Mandi; Li, Yichen; Yuen, Ho Him; He, Ming-liang; | 書刊名 | Journal of Biomedical Science |
卷期 | 29 2022[民111] |
頁次 | 頁(27)1-(27)19 |
分類號 | 415.239 |
關鍵詞 | SARS-CoV-2; Innate immunity; Inflammatory response; Drug targets; |
語文 | 英文(English) |
DOI引用網址 | 10.1186/s12929-022-00811-4 |
英文摘要 | The global pandemic of COVID-19 has caused huge causality and unquantifiable loss of social wealth. The innate immune response is the first line of defense against SARS-CoV-2 infection. However, strong inflammatory response associated with dysregulation of innate immunity causes severe acute respiratory syndrome (SARS) and death. In this review, we update the current knowledge on how SARS-CoV-2 modulates the host innate immune response for its evasion from host defense and its corresponding pathogenesis caused by cytokine storm. We emphasize Type I interferon response and the strategies of evading innate immune defense used by SARS-CoV-2. We also extensively discuss the cells and their function involved in the innate immune response and inflammatory response, as well as the promises and challenges of drugs targeting excessive inflammation for antiviral treatment. This review would help us to figure out the current challenge questions of SARS-CoV-2 infection on innate immunity and directions for future studies. |
本系統之摘要資訊系依該期刊論文摘要之資訊為主。