頁籤選單縮合
題 名 | Phenytoin於造血幹細胞移植之使用=Use of Phenytoin in Hematopoietic Stem Cell Transplantation |
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作 者 | 鄭如君; 謝政智; | 書刊名 | 藥學雜誌 |
卷 期 | 32:3=128 2016.09[民105.09] |
頁 次 | 頁55-60 |
分類號 | 418.21 |
關鍵詞 | 調理療法; 造血幹細胞移植; Phenytoin; Busulfan; Seizure; |
語 文 | 中文(Chinese) |
中文摘要 | 高劑量的 busulfan 經常用於造血幹細胞移植的調理療法,臨床試驗顯示, busulfan 在骨髓摧毀性的治療劑量下,其顯著的神經毒性可能引發全身性強直陣攣發 作1。Phenytoin 廣泛用於預防 busulfan 誘發的癲癇發作,然而 phenytoin 為治療濃度範 圍狹窄的藥品,臨床上須藉由血中濃度監測以達到良好的治療效果,考量 phenytoin 的使用可能引發肝臟毒性,療程長短是否能達穩定狀態,以及與 busulfan 或調理 療程其他藥物之間的交互作用,藉由此案例進一步探討在造血幹細胞移植的族群 phenytoin 是否為理想的預防性抗癲癇藥的選擇。 |
英文摘要 | High-dose busulfan is frequently used in a variety of conditioning regimens for hematopoietic cell transplantation. Early clinical trials, busulfan revealed marked neurotoxicity associated with myeloablative doses, causing seizures that generally are tonic-clonic. Phenytoin has been widely used to treat busulfan-induced seizures. Because of its narrow therapeutic range, it needs drug level monitoring for a better therapeutic effect in clinical use.However, concerns with its use include the risk of hepatotoxicity, the length of time to achieve a steady state, and drug-drug interactions with busulfan and other agents used during conditioning regimens. Through the cases report will further discuss whether phenytoin is a optimal option in the hematopoietic stem cell transplantation population for seizure prevention. |
本系統中英文摘要資訊取自各篇刊載內容。