查詢結果分析
相關文獻
- The Anti-inflammatory Effects of the Bioactive Compounds Isolated from Alpinia officinarum Hance Mediated by the Suppression of NF-kappaB and MAPK Signaling
- Chemical Constituents from the Roots of Zizyphus jujuba Mill. var.spinosa
- Inhibition of Thromboxane Formation as the Antiplatelet Mechanism of 3, 4-Dihydroxyxanthone and Quercetin Pentaacetate
- Curcumin Regulates EZH2/Wnt/β-catenin Pathway in the Mandible and Femur of Ovariectomized Osteoporosis Rats
- Quercetin Blocks the Aggressive Phenotype of Triple-negative Breast Cancer by Inhibiting IGF1/IGF1R-mediated EMT Program
- Effects of Curcumin Gel on Osteoclastogenic Bone Markers in Experimental Periodontitis and Alveolar Bone Loss in Wistar Rats
- Anti-glycation, Anti-hemolysis, and ORAC Activities of Demethylcurcumin and Tetrahydroxycurcumin in Vitro and Reductions of Oxidative Stress in D-galactose-induced BALB/c Mice in Vivo
- Supercritical Assisted Electrospray/Spinning to Produce PVP+Quercetin Microparticles and Microfibers
頁籤選單縮合
題名 | The Anti-inflammatory Effects of the Bioactive Compounds Isolated from Alpinia officinarum Hance Mediated by the Suppression of NF-kappaB and MAPK Signaling |
---|---|
作者 | Li, Chia-yu; Cheng, Szu-en; Wang, Sue-hong; Wu, Jane-yii; Hsieh, Chang-wei; Tsou, Hsi-kai; Tsai, Ming-shiun; | 書刊名 | The Chinese Journal of Physiology |
卷期 | 64:1 2021.01-02[民110.01-02] |
頁次 | 頁32-42 |
分類號 | 414.5 |
關鍵詞 | Alpinia officinarum Hance extract; Anti-inflammatory effects; Curcumin; Galangin; Kaempferol; Quercetin; |
語文 | 英文(English) |
英文摘要 | This study was designed to evaluate the anti‑inflammatory effects of Alpinia officinarum Hance extract (AOE) and identify its main active ingredients. AOE was obtained using a 95% ethanol extraction method. Lipopolysaccharide (LPS) were used to induce an inflammatory response in RAW264.7 cells. The results showed that AOE exerts anti‑inflammatory effects via inhibition of prostaglandin E2 secretion and cyclooxygenase‑2 (COX-2) production. We further analyzed the components of AOE using high-performance liquid chromatography and found that AOE is comprised of several bioactive flavonoids including quercetin (Q), kaempferol (K), galangin (G), and curcumin (C). These four flavonoids effectively inhibited nitric oxide (NO), interleukin (IL)‑1β, IL-6, and tumor necrosis factor-α production. Moreover, they reduced COX-2 and inducible NO synthase expressions via regulation of nuclear factor kappa-light-chain-enhancer of activated B cells and c‑Jun N‑terminal kinase signaling pathways. Furthermore, we compared and contrasted the anti‑inflammatory effects and mechanisms of these four flavonoids at the same dose in the LPS‑induced cell inflammation model. The results showed that C is the most effective inhibitor of LPS‑induced NO production. However, only Q and K effectively attenuated LPS‑induced extracellular signal-regulated kinase and p38 elevations. In conclusion, AOE and its major bioactive compounds exert anti‑inflammatory effects on LPS‑induced inflammation. As A. officinarum Hance is much cheaper than any of its four flavonoids, especially G, we suggest using AOE as an anti‑inflammatory agent. |
本系統之摘要資訊系依該期刊論文摘要之資訊為主。