頁籤選單縮合
| 題 名 | Effectiveness and Evolution of Anti-SARS-CoV-2 Spike Protein Titers after Three Doses of COVID-19 Vaccination in People with HIV |
|---|---|
| 作 者 | Liu, Wang-da; Lin, Meng-shuan; Sun, Hsin-yun; Shih, Ming-chieh; Chuang, Yu-chung; Huang, Yu-shan; Lin, Kuan-yin; Li, Guei-chi; Wu, Pei-ying; Chen, Ling-ya; Liu, Wen-chun; Su, Yi-ching; He, Pu-chi; Chen, Yi-ting; Lin, Chia-yi; Cheng, Yu-chen; Yao, Yi; Yeh, Yi-chen; Liu, Chia-chi; Pan, Mei-yan; Luo, Yu-zhen; Chang, Hsi-yen; Wang, Jann-tay; Sheng, Wang-huei; Hsieh, Szu-min; Chang, Sui-yuan; Hung, Chien-ching; | 書刊名 | Journal of Microbiology, Immunology and Infection |
| 卷 期 | 57:4 2024.08[民113.08] |
| 頁 次 | 頁554-563 |
| 分類號 | 418.293 |
| 關鍵詞 | Serologic response; Humoral immunity; Immunogenicity; mRNA-1273 vaccine; BNT162b2 vaccine; Booster vaccination; |
| 語 文 | 英文(English) |
| DOI | 10.1016/j.jmii.2024.02.004 |
| 英文摘要 | Background: Real-world vaccine effectiveness following the third dose of vaccination against SARS-CoV-2 remains less investigated among people with HIV (PWH). Methods: PWH receiving the third dose of BNT162b2 and mRNA-1273 (either 50- or 100-mg) were enrolled. Participants were followed for 180 days until the fourth dose of COVID-19 vaccination, SARS-CoV-2 infection, seroconversion of anti-nucleocapsid IgG, death, or loss to followup. Anti-spike IgG was determined every 1e3 months. Results: Of 1427 participants undergoing the third-dose COVID-19 vaccination, 632 (44.3%) received 100-mg mRNA-1273, 467 (32.8%) 50-mg mRNA-1273, and 328 (23.0%) BNT162b2 vaccine and the respective rate of SARS-CoV-2 infection or seroconversion of anti-nucleocapsid IgG was 246.1, 280.8 and 245.2 per 1000 person-months of follow-up (log-rank test, p Z 0.28). Factors associated with achieving anti-S IgG titers >1047 BAU/mL included CD4 count <200 cells/mm3 (adjusted odds ratio [aOR], 0.11; 95% CI, 0.04e0.31), plasma HIV RNA >200 copies/mL (aOR, 0.27; 95% CI, 0.09e0.80), having achieved anti-spike IgG >141 BAU/mL within 3 months after primary vaccination (aOR, 3.69; 95% CI, 2.68e5.07), receiving BNT162b2 vaccine as the third dose (aOR, 0.20; 95% CI, 0.10e0.41; reference, 100-mg mRNA-1273), and having previously received two doses of mRNA vaccine in primary vaccination (aOR, 2.46; 95% CI, 1,75-3.45; reference, no exposure to mRNA vaccine). Conclusions: PWH receiving different types of the third dose of COVID-19 vaccine showed similar vaccine effectiveness against SARS-CoV-2 infection. An additional dose with 100-mg mRNA-1273 could generate a higher antibody response than with 50-mg mRNA-1273 and BNT162b2 vaccine. |
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