頁籤選單縮合
| 題 名 | Idiopathic Hypertrophic Pachymeningitis: Report of Five Cases and Review of the Literature |
|---|---|
| 作 者 | Lan,Min-yu; Chang,Yung-yee; Kao,Yi-fen; Wu,Hsiu-shan; Chen,Wei-hsi; Liu,Jia-shou; | 書刊名 | Acta Neurologica Taiwanica |
| 卷 期 | 10:4 2001.12[民90.12] |
| 頁 次 | 頁258-266 |
| 分類號 | 415.823 |
| 關鍵詞 | Pachymeningitis; Cranial nerve palsies; Ataxia; Magnetic resonance imaging; |
| 語 文 | 英文(English) |
| 英文摘要 | Pachymeningitis is a chronic inflammatory disorder of the craniospinal dura and arachnoid membrane characterized by focal of diffuse meningeal hypertrophy. Although various causes of this condition have been found, its etiology is sometimes obscure. We report five patients with idiopathic hypertrophic pachymeningitis (IHP), whose most common clinical features are headache, cranial nerve palsy and ataxia. Magnetic resonance imaging demonstrated thickening of the affected cranial meninges in four patients and diffuse involvement of the cranisopinal meninges in the remaining one. The main pathological findings of the lesions were fibrous hyperplasia and infiltration of chronic inflammatory cells. Oral steroid treatment was effective for all of the patients, but it was later replaced by cycoophosphamide and azathioprine in one patient with relapsed symptoms on tapering steroids and intolerable side effects in another. Symptoms of IHP were mostly attributed to the mass effect of hypertrophic meninges. Arterial or venous compromise and hydrocephalus were other important pathogenic mechanisms. As pachymeningitis may be associated with infectious or autouimune disorders, implementation of extensive surveys to detect underlying causes eticolgies, especially chronic microbial infection, is important before the diagnosis of IHP is made. |
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