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題 名 | Increased Prevalence of Proliferative Retinopathy in Patients with Acromegaly |
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作 者 | Wu, Tzu-en; Chen, Harn-shen; Chen, Harn-shen; Wu, Tzu-en; | 書刊名 | Journal of the Chinese Medical Association |
卷 期 | 81:3 2018.03[民107.03] |
頁 次 | 頁230-235 |
分類號 | 415.663 |
關鍵詞 | Acromegaly; Growth hormone; IGF-1; Proliferative retinopathy; |
語 文 | 英文(English) |
英文摘要 | Background: This pilot study was carried to determine the prevalence of retinopathy, especially proliferative retinopathy, in patients with acromegaly. Methods: We analyzed 43 acromegalic patients and 129 age- and gender-matched patients with type 2 diabetes. The retinopathy status was determined from the medical records based on the ophthalmologist consultations of patients with acromegaly. Color photographs of the macula- and disc-centered views were obtained at an angle of 45° with a fundus camera after pharmacologic-induced mydriasis in patients with type 2 diabetes. Results: Compared with age- and gender-matched patients with type 2 diabetes, the acromegalic patients had lower fasting plasma glucose levels and lower systolic and diastolic blood pressures, but were taller and had higher IGF-1 levels. Any degree of retinopathy was present in 9.3% (4 of 43) of patients with acromegaly and 34.9% (45 of 129) of patients with type 2 diabetes (odds ratio [OR] = 0.191; 95% confidence interval [CI] = 0.064–0.570). Proliferative retinopathy was present in 9.3% (4 of 43) of patients with acromegaly and 9.3% (12 of 129) of patients with type 2 diabetes (OR = 1.000; 95% CI = 0.305–3.281). Non-proliferative retinopathy was absent in patients with acromegaly, but present in 25.9% (33 of 129) of patients with type 2 diabetes. Conclusion: The high proliferative, but absence of non-proliferative retinopathy in our patients with acromegaly may reflect the pathogenic effect of IGF-1 on neovascularization. IGF-1 may play an important role in proliferative retinopathy, but may play no role in non-proliferative retinopathy. |
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