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| 題 名 | Waldenström Macroglobulinemia導致Pseudohypoglycemia之案例報告=A Waldenström Macroglobulinemia Case of Pseudohypoglycemia Caused by Interference of IgM in Glucose Assay |
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| 作 者 | 張智凱; 楊弘翊; 張錦標; 湯勝輝; | 書刊名 | 中華職業醫學雜誌 |
| 卷 期 | 27:2 2020.04[民109.04] |
| 頁 次 | 頁121-131 |
| 分類號 | 415.69 |
| 關鍵詞 | Immunoglobulin M單株免疫球蛋白增高血症; Waldenström macroglobulinemia; WM; Pseudohypoglycemia; Hexokinase; Glucose; |
| 語 文 | 中文(Chinese) |
| 中文摘要 | Waldenström macroglobulinemia (WM)為臨床罕見的Immunoglobulin M單株免疫球蛋白增高血症(IgM Monoclonal Gammopathy);主要為淋巴漿細胞異常大量製造IgM paraprotein。IgM Paraprotein在Olympus AU 680生化分析儀 (Beckman-Coulter, USA)會干擾血糖的酵素法Hexokinase G-6-PDH分析,導致假性低血糖值(Pseudohypoglycemia)之結果。至目前,檢驗室很少有簡易去除IgM干擾的方法。本研究主要探討IgM干擾造成假性低血糖之個案,檢驗室常見使用去離子水及生理食鹽水稀釋檢體,評估降低干擾前後結果之差異,與本院的ACCU CHEK Inform II血糖機分析結果做比較,提供檢驗室快速降低IgM干擾之流程,且能發出準確的血糖報告,以提升醫療品質及病人安全。 |
| 英文摘要 | Waldenström macroglobulinemia (WM), a rare IgM monoclonal gammopathy, is characterized by lymphoplasmacytic cells abnormally producing large amount of IgM paraprotein. On Olympus AU680 analyzer (Beckman-Coulter, USA), glucose level determined by Hexokinase G-6-PDH was interfered with IgM Paraprotein and caused pseudohypoglycemia. As of now, there is not a simple approach to eliminate IgM Paraprotein. The aim of this study is to investigate a pseudohypoglycemia case caused by interference of IgM paraprotein. In the laboratory, plasma samples were diluted with deionized water and normal saline and compared differences between pre-treated and treated samples and utilized ACCU CHEK Inform II glucose meter to analyze results. For health care quality and patient safety, we established a procedure for rapidly eliminating IgM and quickly accurate glucose report. |
本系統中英文摘要資訊取自各篇刊載內容。