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題名 | Swimming Exercise Induced Reversed Expression of miR-96 and Its Target Gene Nav1.3 in Diabetic Peripheral Neuropathy in Rats |
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作者 | Aghdam, Amir Mahmoudi; Shahabi, Parviz; Karimi-Sales, Elham; Ghiasi, Rafigheh; Sadigh-Eteghad, Saeed; Mahmoudi, Javad; Alipour, Mohammad Reza; Sadigh-eteghad, Saeed; Alipour, Mohammad Reza; Karimi-sales, Elham; Aghdam, Amir Mahmoudi; Ghiasi, Rafigheh; Shahabi, Parviz; Mahmoudi, Javad; | 書刊名 | The Chinese Journal of Physiology |
卷期 | 61:2 2018.04[民107.04] |
頁次 | 頁124-129 |
分類號 | 415.6687 |
關鍵詞 | Diabetic neuropathy; Exercise; miR-96; Nav1.3; Rat; Sciatic; |
語文 | 英文(English) |
英文摘要 | Diabetes is a common metabolic disease which leads to diabetic peripheral neuropathy (DPN). Recently, the role of micro-ribonucleic acid-96 (miR-96) in alleviating neuropathic pain by inhibiting the expression of NaV1.3, an isoform of voltage-gated sodium channels, has been shown. Peripheral nerve injuries result in NaV1.3 elevation. Exercise has beneficial role in diabetes management and peripheral neuropathy. However, the effects of exercise on miR-96 and its target gene NaV1.3 in diabetic rats are unknown. Therefore, the present study investigated the effects of exercise training on the expression of miR-96 and NaV1.3 in diabetic rats. For this purpose, rats were randomly divided into four groups: control, exercise, diabetic and diabetic-exercise groups. Type 2 diabetes was induced by a high-fat diet and the administration of streptozotocin (STZ) (35 mg/kg, i.p.). The exercise groups were subjected to swimming exercise 5 days/week for 10 weeks. At the end of the treatment period, thermal pain threshold, determined through the tail-flick test, and the expression levels of miR-96 and its target gene NaV1.3 were determined by reverse transcription -polymerase chain reaction (RT-PCR) in the sciatic nerve tissues of the rats. Data of the present study indicated that diabetes diminished miR-96 expression levels, but significantly upregulated NaV1.3 expression in the sciatic nerve. On exercise training, miR-96 expression was reversed with concurrent downregulation of the NaV1.3 expression. This study introduced a new and potential miRNA-dependent mechanism for exercise-induced protective effects against diabetic thermal hyperalgesia. |
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