頁籤選單縮合
題 名 | Suppression of Isoproterenol-Induced Apoptosis in H9c2 Cardiomyoblast Cells by Daidzein through Activation of Akt |
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作 者 | Hu, Wei-syun; Lin, Yueh-min; Kuo, Wei-wen; Pan, Lung-fa; Yeh, Yu-lan; Li, Yi-hui; Kuo, Chia-hua; Chen, Ray-jade; Padma, V. Vijaya; Chen, Tung-sheng; Huang, Chih-yang; | 書刊名 | The Chinese Journal of Physiology |
卷 期 | 59:6 2016.12[民105.12] |
頁 次 | 頁323-330 |
分類號 | 415.132 |
關鍵詞 | Apoptosis; Daidzein; Estrogen; Heart disease; Isoproterenol; |
語 文 | 英文(English) |
英文摘要 | Increased serum norepinephrine level is one of pathological processes relating to heart disease (HD). Estrogens are considered as potential therapeutics for the treatment of HD; however, estrogen supplementation shows some side-effects, such as increasing the risk of developing breast, endometrial and ovarian cancers. This study investigated the cardio-protective effects of daidzein (Dai), a selective estrogen receptor modulator (SERM) from soy bean extract, in H9c2 cardiomyoblast cells treated with isoproterenol (ISO), a norepinephrine analog. In this in vitro model, H9c2 cells treated with Dai at different concentrations showed no statistical difference in cell viability. TdT-mediated digoxigenin-dUTP nick-end labeling (TUNEL) data and western blotting results indicated that Dai treated-H9c2 cells recovered from the damage induced by ISO. The recovery effects of Dai on ISO-induced damage were blocked by inhibition of Akt activation through adding Akt inhibitor. On the other hand, the fold changes of phosphorylated Akt (p-Akt)/Akt normalized with the control for con, 0.25, 0.5, 1, 3 and 24 h of treatment were 1, 2, 5, 13, 11 and 10, respectively. In conclusion, Dai ameliorates apoptosis of cardiomyoblasts induced by ISO through Akt signaling pathway. |
本系統中英文摘要資訊取自各篇刊載內容。