頁籤選單縮合
題名 | Association of Caveolin-1 Genotypes with Renal Cell Carcinoma Risk in Taiwan |
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作者 | Chang, Wen-shin; Tsai, Chia-wen; Wang, Shu-ming; Wang, Shyi-wu; Wu, Hsi-chin; Ji, Hong-xue; Lin, Chih-hsueh; Wang, Zhi-hong; Chou, Jou-chun; Bau, Da-tian; Wang, Paulus S.; | 書刊名 | The Chinese Journal of Physiology |
卷期 | 57:4 2014.08[民103.08] |
頁次 | 頁220-226 |
分類號 | 415.818 |
關鍵詞 | Caveolin-1; Genotype; Renal cell carcinoma; Single nucleotide polymorphisms; |
語文 | 英文(English) |
英文摘要 | The alteration of caveolin-1 (Cav-1) during carcinogenesis is of great interest and its over-expression in the tumor cell cytoplasm can predict a poor prognosis of renal cell carcinoma (RCC). However, whether the over-expression in RCC is associated with inherited polymorphism is not clear. In this hospital-based case-control study, the association of Cav-1 genotypes with RCC risk in a central Taiwanese population was investigated. Ninety-two patients with RCC and five hundred and eighty of age/gender-matched healthy controls were recruited and genotyped for six polymorphic sites at Cav-1, C521A (rs1997623), G14713A (rs3807987), G21985A (rs12672038), T28608A (rs3757733), T29107A (rs7804372), and G32124A (rs3807992). The results showed that there were statistically different distributions of the genotypic (P = 0.0170 and 0.0011) and allelic (P = 0.0033 and 0.0352) frequencies for the Cav-1 G14713A and T29107A polymorphisms among RCC patients and control subjects, respectively. As for the haplotype analysis, subjects carrying “GG/AT or GG/AA” at Cav-1 G14713A/T29107A showed a 2.06-fold increased odds ratio of RCC compared to those with GG/TT, while those of any other combinations were of unaltered odds ratios. In conclusion, this is the first report providing evidence showing that Cav-1 genotype is associated with RCC. The results showed that the G allele of the Cav-1 G14713A and the A allele of the Cav-1 T29107A are risky genetic factors for RCC susceptibility and the combinative GG/AT or GG/AA haplotype at Cav-1 G14713A/T29107A can serve as one of the RCC predictors for Taiwanese. |
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