頁籤選單縮合
題名 | Regulation of Intermittent Hypoxia on Brain Dopamine in Amphetaminized Rats |
---|---|
作者 | Yu, Po-ling; Cheng, Shu-yun; Chou, Jou-chun; Pan, Wynn H. T.; Wang, Shyi-wu; Wang, Paulus S.; | 書刊名 | The Chinese Journal of Physiology |
卷期 | 58:4 2015.08[民104.08] |
頁次 | 頁219-227 |
分類號 | 415.146 |
關鍵詞 | Amphetamine; Angiotensin II; Dopamine; Intermittent hypoxia; Microdialysis; Prolactin; |
語文 | 英文(English) |
英文摘要 | We investigated intermittent hypoxia (IH) on dopamine (DA) release in rat brain treated with or without amphetamine (AMPH). Rats were divided into four groups including normoxia, IH, AMPH, and AMPH + IH treatments. The cerebrospinal fluid (CSF) was collected and the DA levels were detected by high performance liquid chromatography (HPLC). The plasma prolactin (PRL) concentration was measured by radioimmunoassay (RIA). We found that IH reduced basal DA concentration in media prefrontal cortex (mPFC), but increased that in striatum, where DA level was also increased in rats treated with AMPH or AMPH + IH. Angiotensin II (Ang II) increased the DA release in mPFC and striatum and this effect was enhanced in AMPH + IH group. The stimulatory effect of IH on plasma PRL was attenuated in presence of AMPH. Tyrosine hydroxylase (TH) expression was decreased by IH, but increased by AMPH + IH in mPFC. IH or AMPH treatment decreased the expression of vesicular monoamine transporter-2 (VMAT-2) in rat brain. These data suggested that IH altered the DA release and changed the protein expression levels in different parts of rat brain treated with AMPH. IH may play a role in regulating DA metabolism in AMPH addiction. |
本系統之摘要資訊系依該期刊論文摘要之資訊為主。