頁籤選單縮合
| 題 名 | Parathyroid Carcinoma in a Patient with Primary Hyperparathyroidism: A Case Report |
|---|---|
| 作 者 | Ke, Guan-ting; Chu, Chih-hsun; Hung, Hao-chang; | 書刊名 | Formosan Journal of Endocrinology and Metabolism |
| 卷 期 | 15:1 2024.06[民113.06] |
| 頁 次 | 頁41-46 |
| 分類號 | 415.662 |
| 關鍵詞 | Hypercalcemia; Primary hyperparathyroidism; Parathyroid carcinoma; |
| 語 文 | 英文(English) |
| DOI | 10.6856/FJEM.202406_15(1).0006 |
| 英文摘要 | Background. Parathyroid carcinoma is a rare cause of primary hyperparathyroidism, which is usually caused by a parathyroid adenoma and occasionally by primary parathyroid hyperplasia. Methods: We present a case of parathyroid carcinoma, manifesting as hyperparathyroidism with hypercalcemic crisis. Results: A 71 years-old woman with a history of thyroid goiter status post partial thyroidectomy who presented with general weakness and drowsy consciousness for 4 days. Hypercalcemia along with elevated iPTH level was demonstrated. Hyperfunctional parathyroid nodules in the left thyroid fossa were localized by sonography and parathyroid scan. The patient underwent successful subtotal parathyroidectomy with left parathyroid gland and lymph node removed. The pathology was parathyroid hyperplasia but the neck lymph node was metastatic carcinoma with parathyroid origin. Hyperparathyroidism with hypercalcemia was still demonstrated after surgery. Further reoperation was scheduled but withheld because of severe sepsis condition, which eventually led to her death. Conclusion: Parathyroid carcinoma is rare and may be indistinguishable when primary hyperparathyroidism is present. The final diagnosis depends on the pathology and is usually made at the time of surgery or post operation. Operation with extent resection is the mainstay treatment. Combining localization images and intra-operative iPTH monitoring may improve the success rate of operation. The prognosis for parathyroid cancer vary based on several factors, including stage of cancer, a person's age, general health, and how well the treatment plan works. |
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