頁籤選單縮合
題名 | High Level Antibodies to TORCH in the IVIG Preparation from Taiwanese= |
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作者 | Chou, Ya-ling; Hsieh, Kao-hsian; Perng, Cherng-lih; Fan, Hueng-chuen; Tien, Chiung-hsi; Wang, Chih-chien; Chen, Shyi-jou; Chang, Fung-wei; |
期刊 | Journal of the Chinese Medical Association |
出版日期 | 20190600 |
卷期 | 82:6 2019.06[民108.06] |
頁次 | 頁510-514 |
分類號 | 414.82 |
語文 | eng |
關鍵詞 | Antibodies; Intravenous immunoglobulins; TORCH infections; |
英文摘要 | Background: Congenital TORCH (toxoplasmosis, other viruses [varicella-zoster virus, VZV, etc.], rubella, cytomegalovirus [CMV], Herpes simplex virus [HSV]) infections are major causes of prenatal, perinatal, and postnatal morbidity and mortality. Although treatment or prevention strategies are available for these pathogens, all drugs may not be safe during the pregnancy. The aim of this study is to measure the antibodies (Abs) concentration in the intravenous immunoglobulin (IVIG) preparation to evaluate the therapeutic potential for TORCH infection. Methods: We tested the only one commercial IVIG preparation from Taiwanese for the presence of Abs against Toxoplasma gondii, VZV, Epstein–Barr virus (EBV), measles, mumps, rubella, CMV, HSV type 1 (HSV-1), and HSV type 2 (HSV-2) by using enzymelinked immunosorbent assay or chemiluminescent microparticle immunoassay. Results: In our study, the median level (range) of anti-CMV immunoglobulin G (IgG) is > 250 (All > 250) (arbitrary unit, AU)/mL, anti-EBV > 200 (All > 200) (relative unit, RU)/mL, anti-HSV > 200 (152.75 to >200) RU/mL, anti-VZV > 5000 (All > 5000) IU/L, antimeasles > 5000 (All > 5000) IU/L, anti-mumps > 200 (156.5 to > 200) RU/mL, anti-rubella 209.8 IU/mL (192.7 to 238.5), and antiToxoplasma is 14.05 (12.3 to 16) IU/mL. There was not any immunoglobulin M (IgM) against HSV, VZV, mumps, measles, rubella, CMV, EBV, and Toxoplasma in the “Taiwan Blood Services Foundation” IVIG preparations. Conclusion: There was high activity against T. gondii, VZV, EBV, measles, mumps, rubella, CMV, HSV-1, and HSV-2 in all IVIG batches. Further investigation is warranted to confirm the efficacy of IVIG from Taiwanese for congenital TORCH infections. |
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