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題名 | Terbinafine引起急性廣泛性發疹性膿皰症=A Severe Case of Terbinafine-induced Acute Generalized Exanthematous Pustulosis |
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作者 | 侯瑞良; 王惠蓉; 鄭宛玲; | 書刊名 | 藥學雜誌 |
卷期 | 35:1=138 2019.03[民108.03] |
頁次 | 頁108-114 |
分類號 | 418.284 |
關鍵詞 | 急性廣泛性發疹性膿皰症; Terbinafine; AGEP; Acute generalized exanthematous pustulosis; |
語文 | 中文(Chinese) |
中文摘要 | 急性廣泛性發疹性膿皰症 (acute generalized exanthematous pustulosis/AGEP),是一 種罕見的皮膚疾病,90%為藥物引起之嚴重不良反應,其特徵為病人使用某些藥品後 會全身泛紅,急性發生數十至數百、甚至數千個無菌、非毛囊、針頭大小的膿皰,膿 皰出現在水腫的紅斑處,病灶以群聚為主,發病期間病人常常有發燒、嗜中性白血球 細胞數目增加的現象,大多數病人在停藥後會自行緩解、癒合,最後全身性脫屑。本 文病例為38歲男性,使用 terbinafine 後引發 AGEP 立即停藥,住院期間經過支持性療 法及症狀治療後,15天內症狀緩解,從出現症狀至出院共計21天。 |
英文摘要 | Acute generalized exanthematous pustulosis (AGEP) is a severe cutaneous reaction characterized by an acute episode of numerous non-follicular sterile postules clustering over the erythematous-oedematous skin combined with fever and peripheral blood leukocytosis. Ninety percent of AGEP cases are associated with adverse drug reaction. Terbinafine is the most common anti-fungal medication that links to the development of AGEP, but the reaction usually resolves after drug withdrawal. We report a severe case of terbinafine-induced AGEP in a 38-year-old male. The patient was treated with anti-histamine, steroids, and supportive measures. The symptoms resolved within 15 days. The course of treatment, from the onset of symptom to discharge, was 21 days. |
本系統之摘要資訊系依該期刊論文摘要之資訊為主。