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題名 | 下咽癌併第二原發食道腫瘤生成之研究=A Study of Second Esophageal Neoplasia in Hypopharyngeal Carcinoma |
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作者 | 劉哲維; 黃澤人; 王誌群; 楊顓謙; 連景峯; | 書刊名 | 臺灣耳鼻喉頭頸外科雜誌 |
卷期 | 52:4 2017.10-12[民106.10-12] |
頁次 | 頁140-144 |
分類號 | 416.89 |
關鍵詞 | 下咽癌; 第二原發食道腫瘤; Hypopharyngeal cancer; Second esophageal neoplasia; |
語文 | 中文(Chinese) |
中文摘要 | 背景:下咽部鱗狀細胞癌有著極差的預後,第二原發食道腫瘤的高發生率是個主要的原因。本研究旨在分析下咽癌併發第二原發食道腫瘤生成的相關因素,並了解第二原發食道腫瘤的疾病及其對整體存活率(overall survival)之影響。方法:回溯性收集了2007年7月至2015年7月間,在本院接受手術治療的下咽癌患者。排除過去頸部和下咽部曾經接受放射治療或手術後追蹤不到12個月的患者,分析病患食道侵犯位置、第二原發食道腫瘤被檢測的時間、年齡、腫瘤分期及存活時間。結果:共收集185名患者,平均年齡為60 ± 10歲(34~81歲)。存活患者的平均追蹤時間為48 ± 25月(12~118月)。其中51(27.6%)名患者發現第二原發食道腫瘤生成,包括40名食道鱗狀細胞癌和11名嚴重分化不良。多變異分析的初步結果顯示第二原發食道腫瘤形成與年齡(OR 2.642, 95% CI 1.109-6.295,P = 0.028)之間具有顯著相關性。結論:年齡和下咽癌併發第二原發食道腫瘤生成的發生率有顯著的關聯。年齡小於等於60歲的下咽癌患者需特別密切監視第二原發食道腫瘤生成,特別是食道中段三分之一的位置,追蹤時間至少4年。 |
英文摘要 | BACKGROUND: Hypopharyngeal squamous cell carcinoma has an extremely poor prognosis. The high incidence rate of second esophageal tumors is one of the major causes. To improve the prognosis, this study aimed to clarify if the second esophageal neoplasia is associated with demographic and clinicopathological factors, and to understand its impact on overall survival. METHOD: Patients who underwent resection of hypopharyngeal tumor at our hospital between July 2007 and July 2015 were retrospectively enrolled. Data regarding demographic and clinicopathological factors, invaded location of the esophagus and survival time were collected and analyzed. RESULTS: A total of 185 patients were included with a mean age of 60 ± 10 years (range, 34-81 years). There were 185 male and 2 female patients. Mean follow-up for survival patients was 48 ± 25 months (range, 12-118 months). Second esophageal tumors were found in 51 (27.6%) patients, which included 40 for esophageal squamous cell carcinoma and 11 for severe dysplasia. The results of multivariate analyses showed a significant correlation between second esophageal neoplasia and age (OR 2.642, 95%CI 1.109-6.295, P = 0.028) and a significantly worse overall survival for patients with second esophageal neoplasia. CONCLUSION: The hypopharyngeal carcinoma patients with younger age (≤60 years old) was found associated with an increased risk for second esophageal neoplasia in the study. Close surveillance for second esophageal neoplasm (especially middle third) is required for at least 4 years after the diagnosis of hypopharyngeal carcinoma. |
本系統之摘要資訊系依該期刊論文摘要之資訊為主。