頁籤選單縮合
題名 | Prognostic Effects of O⁶-Methylguanine DNA Methyltransferase Promoter Hypermethylation in High-Grade Glioma Patients with Carmustine Wafer Implants |
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作 者 | Chen, Mao-yu; Pai, Ping-ching; Jung, Shih Ming; Chuang, Chi-cheng; Chang, Chen-nen; Wei, Kuo-chen; | 書刊名 | Formosan Journal of Surgery |
卷期 | 50:2 2017.04[民106.04] |
頁次 | 頁45-51 |
分類號 | 415.138 |
關鍵詞 | Carmustine wafer; Glioblastoma multiforme; Gross total resection; High-grade gliomas; O⁶-methylguanine-DNA-methyltransferase; |
語文 | 英文(English) |
英文摘要 | Background: Local chemotherapy with carmustine (BCNU) wafer implantation has survival benefits for malignant glioma patients. However, available data regarding its association with O6-methylguanine-DNA-methyltransferase (MGMT) are scant. Purpose: To evaluate whether MGMT hypermethylation has prognostic effects in malignant glioma patients with interstitial BCNU wafer implants. Methods: From September 2004 to August 2007, 32 patients with malignant gliomas underwent surgical resection plus interstitial BCNU wafer implantation at our hospital. Results and Conclusion: BCNU wafer implantation was performed in 18 patients with newly diagnosed gliomas and in 14 with recurrent gliomas. All patients had a Karnofsky performance status of ≥70. The median age was 51 years. At a median follow-up of 31 months, the 1- and 2-year overall survival (OS) rate was 43% and 22%, respectively. OS rates did not significantly differ between the newly diagnosed and recurrent patients. Gross total tumor resection was achieved in 19 (59%) patients, and MGMT hypermethylation was noted in 13 (41%) tumor specimens. Multivariate analysis demonstrated that patients with MGMT hypermethylation in their tumors and gross total tumor removal have more favorable survival rates (P = 0.03). |
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