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題名 | 親子代葉酸營養攝取量對子代C57BL/6小鼠生長與肺組織癌化及發炎調轉能量代謝訊息傳遞分子表現之影響=Effects of Parental and Offspring Folate Intake on the Offspring's Growth and Inflammation-associated Lung Bioenergetics Signaling in C57BL/6 Mice |
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作者 | 潘富子; 尉遲浤圳; 劉奕方; 許瑞芬; Pan, Fu-zi; Yu Chi, Hong-jun; Liew, Yih-fong; Syu Huang, Rwei-fen; |
期刊 | 臺灣營養學會雜誌 |
出版日期 | 20160900 |
卷期 | 41:3 2016.09[民105.09] |
頁次 | 頁75-84 |
分類號 | 411.38 |
語文 | chi |
關鍵詞 | 低葉酸攝取; 發炎因子; 肺癌化; 親子代; 能量代謝訊息傳遞; Low folate intake; Parental and offspring; Inflammatory signal; Lung abnormality; Bioenergetics; Lipid metabolism; |
中文摘要 | 本研究擬探討親子代葉酸營養攝取量對子代生長與肺組織之癌化及發炎調轉能量代謝訊息傳遞分子表現之影響。以3週齡C57BL/6雌鼠,投與葉酸正常飲食(對照組:C)及低葉酸飲食(低葉酸組:LF)4星期後,進行配種至母鼠懷孕產出幼鼠子代。斷奶子代再依其親代飲食分為三組:親代葉酸對照組-子代葉酸對照控(C-C)、親代葉酸對照組-子代低葉酸組(C-LF)、及親代低葉酸組-子代低葉酸組(LF-LF)。實驗13週後犧牲子代收集肺臟組織進行分子病變分析。結果顯示,LF-LF組比C-C及C-LF組顯著影響子代低出生體重及生長發育遲緩。LF-LF組顯著增加子代肺組織NF- B、mTOR蛋白表現及促進調控脂質代謝酵素ATP citrate lyase的蛋白表現。雖然癌化相關Shh and E-cadherin訊息蛋白表現於三組間並無顯著差異,合併親子代低葉酸飲食誘發子代肺臟mTOR訊息調轉脂質生合成,可能增加子代罹患肺癌的風險。未來仍需要更多研究確認親子代低葉酸飲食誘發子代肺組織癌化進展。 |
英文摘要 | Aims of the study were to investigate the effects of parental and offspring folate intake on the offspring's growth and inflammation-associated lung bioenergetics signaling in C57BL/6 mice. Two groups of C57BL/6 mice (n =6/group) at 3 weeks old were randomly assigned to a control (C) diet with the recommended amount of folic acid (FA: 2 mg/kg diet) or a low-folic acid (LF) diet (0.5 mg/kg diet) for 4 weeks and during pregnancy. After delivery, the offspring from both groups at 21 days of weaning age were divided into three groups (n =4 or 5/group) and fed the C and LF diets, designated the parental C-offspring C (C-C), parental C-offspring LF (C-LF), and parental LF-offspring LF diets (LF-LF) for 13 weeks. Data revealed that average weight gains of the LF-LF group were significantly lower than those of the C-C and C-LF groups (p <0.05). Protein expressions of the inflammatory factor nuclear factor (NF)- B, the metabolic stressor of mammalian target of rapamycin (mTOR), and the rate-limiting enzyme of lipid biosynthesis, ATP-citrate lyase, were upregulated in lung tissues of the LF-LF group compared to those expressed in the C-C and C-LF groups (p <0.05). Expressions of the carcinogenic signalers, sonic hedgehog and E-cadherin, did not differ in lung tissues of the three groups. Taken together, the data demonstrated that the combined parental and offspring's LF diets significantly retarded offspring growth and inflammation-associated lung bioenergetics signaling in C57BL/6 mice. Whether the dual LF dietary exposure further promotes lung cancer development in offspring mice requires further studies. |
本系統之摘要資訊系依該期刊論文摘要之資訊為主。