查詢結果分析
相關文獻
- Severe Extensive Bone Marrow Necrosis From Miliary Tuberculosis Without Granulomas and Pulmonary Presentations
- Bone Marrow Necrosis and Malignancy: A Single Institution Experience
- Life Threatening Pancytopenia with Azathioprine in a Systemic Lupus Erythematosus Patient
- 滅殺除癌錠使用在乾癬病人引起之皮膚糜爛及潰瘍
- 噬血性淋巴組織球增生症的診斷與治療
- 臨床病理解剖討論會(四十一)--年輕男性發燒併肝脾腫大及血球低下
- 全血球低下之個案報告
- Low-Dose Methotrexate-induced Severe Pancytopenia in One Patient with Psoriasis Undergoing Hemodialysis
頁籤選單縮合
題名 | Severe Extensive Bone Marrow Necrosis From Miliary Tuberculosis Without Granulomas and Pulmonary Presentations=瀰漫性結核感染引起的嚴重廣泛性骨髓壞死且缺乏骨髓肉芽腫及肺部症狀 |
---|---|
作 者 | 李昀璇; 洪英中; 楊靜芬; 吳宏達; 黃鈴茹; 曾成槐; 劉峻宇; | 書刊名 | Journal of the Chinese Medical Association |
卷期 | 73:4 2010.04[民99.04] |
頁次 | 頁208-211+CA35 |
關鍵詞 | 骨髓壞死; 瀰漫性結核感染; 全血球低下; Bone marrow necrosis; Miliary tuberculosis; Pancytopenia; |
語文 | 英文(English) |
英文摘要 | Bone marrow necrosis (BMN) is a rare clinicopathologic entity caused by hypoxemia after failure of the microcirculation, which frequently manifests with bone pain, fever, and peripheral cytopenia. In most reported cases of BMN resulting from miliary tuberculosis (TB), the presence of marrow granulomas, pulmonary infiltrates and/or extrapulmonary involvement is common. We report a female patient with extensive BMN from miliary TB, whose initial presentation was only severe peripheral cytopenia with extensive marrow necrosis, with neither evident pulmonary manifestations nor granulomas in the marrow biopsy. Serial Ziehl–Neelsen stains and Mycobacterium tuberculosis cultures were negative. The diagnosis of suspected miliary TB was made by consecutive positive results from polymerase chain reaction analysis for TB of marrow samples at 2 separate examination time points and a good treatment response to anti-TB therapy. Magnetic resonance imaging showed a geographic pattern of multiple signal abnormalities, indicating bone infarcts over the bilateral iliac bones and T-L-spine vertebral bodies, compatible with extensive BMN. The unusual presentation of extensive BMN with severe peripheral cytopenia in the absence of granulomas or pulmonary presentations should alert clinical physicians in epidemic areas. We discuss the use of polymerase chain reaction analysis for TB and magnetic resonance imaging for diagnosis of these patients. |
本系統之摘要資訊系依該期刊論文摘要之資訊為主。