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相關文獻
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頁籤選單縮合
題名 | 急性肝衰竭的治療選擇--NAC=Use of N-acetylcysteine for Acute Liver Failure |
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作者 | 游佳玲; 江俐慧; 鄧新棠; 陳琦華; 卓偉民; | 書刊名 | 藥學雜誌 |
卷期 | 32:4=129 2016.12[民105.12] |
頁次 | 頁76-81 |
分類號 | 416.246 |
關鍵詞 | 急性肝衰竭; 肝臟移植; N-acetylcysteine; NAC; |
語文 | 中文(Chinese) |
中文摘要 | 急性肝衰竭 (又稱猛爆性肝衰竭) 是病人肝臟突然喪失功能,危及生命的臨床急 症。而肝臟移植往往是最後且唯一的治療選擇。急性肝衰竭的定義為病人之前無肝臟 疾病,在黃疸出現的26週內發生肝腦病變,伴隨發生凝血功能異常 (國際標準凝血時 間比值,INR > 1.5)。病因有很多,包括藥物、病毒性肝炎與感染等等。眾所周知, N-acetylcysteine (NAC) 是 Acetaminophen 中毒的解毒劑。一個隨機雙盲臨床試驗的結 果顯示,對於非 acetaminophen 引起急性肝衰竭的輕度肝腦病變病人,NAC 可以增 加其不需肝移植而仍可存活的機率 (transplant-free survival),延緩進入肝臟移植的時 間。NAC 治療療程的費用不昂貴且安全性高,可作為急性肝衰竭治療選擇之一。 |
英文摘要 | Acute liver failure (sometimes referred to as fulminant hepatic failure) is a lifethreatening medical emergency characterized by the rapid deterioration of liver function.Liver transplantation is a last and only treatment measure to survive. Acute liver failure is defined as onset of coagulopathy (international normalised ratio 1.5 or greater) and encephalopathy in a person without pre-existing liver disease, and with an illness of less than 26 weeks in duration. Acute liver failure can be induced by various etiologies, included drugs, viral hepatitis, infections and so on. N-acetylcysteine (NAC) is well known as an antidote for acetaminophen poisoning. In a prospective, randomized, double-blind trial, N-Acetylcysteine (NAC) improved transplant-free survival in patients with non-acetaminophen-Induced acute liver failure when administered in early stages of hepatic encephalopathy. Treatment with NAC, which is safe and relatively inexpensive, would be a viable treatment option for acute liver failure patients. |
本系統之摘要資訊系依該期刊論文摘要之資訊為主。