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頁籤選單縮合
題 名 | 人工生殖--試管嬰兒科技之近代發展=Current Assisted Reproductive Technologies |
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作 者 | 陳妙汝; 廖榮華; | 書刊名 | 秀傳醫學雜誌 |
卷 期 | 15:1/2 2016.06[民105.06] |
頁 次 | 頁57-63 |
分類號 | 417.125 |
關鍵詞 | 人工生殖; 體外受精; 胚胎; 玻璃化冷凍術; 縮時攝影; Assisted reproduction; In vitro fertilization; Embryo; Vitrification; Time-lapse; |
語 文 | 中文(Chinese) |
中文摘要 | 體外受精(In Vitro Fertilization; IVF) 即俗稱試管嬰兒,近年在實驗室的各項技術有些新的發展,使懷孕率及活產率明顯提高。卵巢中卵泡庫存量可預測是否容易引卵、是否容易成功懷孕。應用控制低氧環境的三氣體培養箱及胚胎培養液的持續改良,使體外培養至第五天的囊胚形成率高達50-70 %;再者,玻璃化冷凍術(Vitrification)在學者不斷努力己改良後,解凍後的胚胎或卵子存活率已大幅提升。綜此,無論是在取卵週期植入新鮮囊胚,或先行冷凍囊胚,待調整受術妻的內分泌及子宮內膜,到較適合胚胎著床的情況下再行解凍胚胎植入,已使目前試管嬰兒(不分年齡)的懷孕率達30%以上。雷射輔助切片的應用、囊胚培養率的提高、玻璃化冷凍成功率的提升、染色體或基因分析技術的精進、胚胎縮時攝影(Time-lapse) 科技的問世等相輔相成,使得選擇染色體或基因正常的胚胎做植入不再只是理想。 |
英文摘要 | The pregnancy rate and live birth rate for In Vitro Fertilization (IVF), also known as "test-tube babies", are currently increasing along with technological advancements. The ovarian reserve plays a crucial role in predicting the response and outcome in couples prior to In Vitro Fertilization. The application of a triple gas incubator to reduce the oxygen concentration and the persistent improvement of culture media have led to a high blastocyst formation rate on Day 5 or 6 (50-70%). Moreover, the improvement of vitrification techniques has increase the post-thaw survival rates of embryos and oocytes. Overall, either transferring fresh blastocysts or freezing embryos in an oocyte retrieval cycle and then transferring the frozen embryos after establishing a more receptive endometrium in another cycle can achieve pregnancy rates over 30%. In sum, the use of laser assisted hatching, the high blastocyst formation rate, the increasing of post-thaw survival rates after vitrification, the improvement of chromosome or genetic diagnosis techniques and the introduction of time-lapse imaging systems for embryo monitoring have made it possible to select euploid or genetic normal embryos for transfer. |
本系統中英文摘要資訊取自各篇刊載內容。