頁籤選單縮合
題名 | Safety and Efficacy of Daptomycin for the Treatment of Hospitalized Adult Patients in Taiwan with Severe Staphylococcal Infections |
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作者 | Lai, Chung-chih; Sheng, Wang-huei; Wang, Jann-tay; Liao, Chun-hsin; Ho, Mao-wang; Chen, Chwen-je; Chen, Der-li; Chou, Ming-uen; Lee, Chien-ming; Lin, Yee-chun; Pong, Ming-ye; Chang, Shan-chwen; | 書刊名 | Journal of Microbiology, Immunology and Infection |
卷期 | 45:1 2012.02[民101.02] |
頁次 | 頁52-57 |
分類號 | 418.2216 |
關鍵詞 | Daptomycin; Methicillin-resistant Staphylococcus aureus; Serious infection; |
語文 | 英文(English) |
英文摘要 | Background and Purpose: The safety and efficacy of treating serious infections caused by Staphylococcus aureus with daptomycin in a Taiwanese population were studied. Methods: A retrospective, multicenter study was performed in Taiwan between December 2007 and June 2009. This study included adult hospitalized patients who had received intravenous daptomycin therapy for infections caused by S aureus. All patients were followed until discharge from the hospital or death. Results: A total of 52 patients (males, nZ44; median age: 62 years) were evaluated. Infections included complicated skin and soft-tissue infections (nZ14), catheter-related bacteremia (nZ14), osteomyelitis and septic arthritis (nZ12), endovascular infections and endocarditis (nZ11), and urinary tract infections (nZ1). Overall, 47 (90.4%) patients were successfully treated and their clinical symptoms were resolved. Adverse effects related to daptomycin were detected in nine patients, but none were required to discontinue daptomycin.Conclusion: The results support daptomycin as an effective and safe treatment for staphylococcal infections in Taiwanese populations. |
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