頁籤選單縮合
題名 | Plasma Soluble CD30 Level Correlates Negatively with Age in Children= |
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作者 | Chen, Jung-Yu; Fu, Lin-Shien; Chu, Jao-Jia; Chen, Hou-Chuan; Chi, Chin-Shiang; |
期刊 | 微免與感染雜誌 |
出版日期 | 20070400 |
卷期 | 40:2 2007.04[民96.04] |
頁次 | 頁168-172 |
分類號 | 414.82 |
語文 | eng |
關鍵詞 | Age factors; Antigens; CD30; Cytokines; T-lymphocytes; |
英文摘要 | Background and Purpose: Atopic diseases are thought to be associated with cytokine-mediated immune dysregulation, for example, a T helper cell type 1/2 (Th1/Th2) imbalance. CD30 is proposed to be one of the surrogate markers for Th2 immunity. In this study, we investigated whether CD30 is a good marker for atopy and Th2 predominance in a pediatric population. Methods: This study included 61 children with atopy and 27 normal controls. The expression of CD30 on the surface of T and B lymphocytes and soluble CD30 (sCD30) in plasma was determined. Results: There was no difference in the surface expression of CD30 on B or T lymphocytes. Similarly, sCD30 levels in plasma were not different between the 2 groups. Nevertheless, we found a strong negative correlation between sCD30 and age in the control group (r = –0.72, p<0.001; sCD30 = 76.1 – 5.18 × age) as well as in the atopy group (r = –0.45, p<0.01; sCD30 = 61.1 – 3.56 × age). Conclusions: An inverse relationship was found between age and sCD30 level in children. However, our findings suggest that CD30 is not a good marker for atopic disease and that further studies on sCD30 levels must take age into consideration. |
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