查詢結果分析
相關文獻
- Invasive Vulvular Extramammary Paget's Disease with HER-2/neu Overexpression--A Case Report
- 外陰Paget's病變的案例報告與文獻探討
- Vulvar Schwannoma: A Case Report
- Paget's Disease of the Vulva: A Case Report
- 女性外陰的佩吉氏症
- Newborns with Ambiguous Genitalia, Impalpable Gonads, and Hyperpigmentation
- Liposarcoma of the Vulva
- Radiotherapy for Extramammary Paget's Disease of the Vulva: Report of Two Cases
- 女陰汗管瘤--15例病例回顧
- 外陰癌最新分期的比較
頁籤選單縮合
題 名 | Invasive Vulvular Extramammary Paget's Disease with HER-2/neu Overexpression--A Case Report=外陰部侵襲性乳房外柏杰氏病併Her-2/neu過度表現--病例報告 |
---|---|
作 者 | 謝綺瀅; 張閔翔; 陳右昇; 游彥辰; 阮廷倫; 張克中; 林佐武; | 書刊名 | 臺灣整形外科醫學會雜誌 |
卷 期 | 26:3 2017.09[民106.09] |
頁 次 | 頁338-346 |
分類號 | 415.691 |
關鍵詞 | 乳房外柏杰氏病; 外陰; 表皮內惡性腫瘤; Extramammary paget's disease; EMPD; HER-2; Vulvular; |
語 文 | 英文(English) |
中文摘要 | 背景:乳房外柏杰氏病為罕見之表皮內惡性腫瘤,少數病人會發展成侵襲性癌症。部分案例會類似乳癌過度表現Her-2/neu蛋白質,這類案例可能會有較高的復發率與較差的存活率。目的及目標:我們利用免疫染色方法找出Her-2/neu蛋白質,希望藉由這個案例拋磚引玉提高大家對這個基因表現的注意,而能有更多研究來找出有Her-2/neu這類案例與疾病嚴重程度的關聯。進一步,希望能提供以Her-2/neu基因為標靶治療的可能性。材料及方法:我們報告一位六十歲女性有外陰部侵襲性乳房外柏杰氏病,其初期表現為外陰部類濕疹性斑塊與多發腫瘤,病人接受外陰切除與淋巴採驗後發現為乳房外柏杰氏病合併多發腺癌。手術治療主要採取外陰廣泛切除與分層植皮手術,術後復原情況良好,三年追蹤並未復發。結果:免疫染色發現腫瘤細胞過度表現Her-2/neu蛋白,可能解釋該病人病況為何較嚴重。結論: 一來希望藉此病例提高對此一罕見疾病之認知,二來希望更多研究能進一步探討腫瘤細胞過度表現Her-2/neu蛋白與疾病的嚴重程度,未來進而研究考慮標靶治療的成效。 |
英文摘要 | Background: Extramammary Paget’s disease (EMPD) is an uncommon intraepithelial malignancy, and few cases develop into invasive or metastatic adenocarcinoma. Similar to breast cancer, Her-2/neu overexpression in EMPD has been also considered as a prognostic factor for high recurrence rates and poor prognosis. Aim and Objectives: We use immunohistochemistry study to identify Her-2/neu and we would like to raise attentions to the correlation between overexpressed Her-2/neu and the severity of the disease. Furthermore, with more studies, Her-2/neu positive patients may benefit from targeted therapy to Her-2/neu. Materials and Methods: We report a case of invasive vulvular EMPD in a 60-year-old woman, who had eczematoid plaques with multiple nodules in the perineum. She underwent wide excision with right lymph node dissection and split-thickness skin graft for reconstruction. She recovered well postoperatively. Results: A microscopic examination revealed widespread EMPD and multifocal invasive adenocarcinomas. An immunohistochemical study found that the tumor cells were positive for Her-2/neu protein, which might explain the EMPD aggressiveness in this patient. Conclusions: First, we would like to review this rare but increasing encountered disease. More researches could be devoted to the overexpressed Her-2/neu and the severity of the EMPD disease. Furthermore, anti-Her-2/neu drugs may be an option of adjuvant therapy. |
本系統中英文摘要資訊取自各篇刊載內容。