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題名 | Concurrent Chemoradiotherapy in Elderly Patients with Muscle-Invasive Bladder Cancer: A Single-Center Experience |
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作者 | Lee, Yu-ting; Wu, Yi-tsui; Yen, Cheuh-chuan; Chang, Mu-hsin; Chang, Yen-hwa; Chung, Hsiao-jen; Lin, Tzu-ping; Liu, Chia-jen; Liu, Jin-hwang; | 書刊名 | Journal of Cancer Research and Practice |
卷期 | 3:3 2016.09[民105.09] |
頁次 | 頁73-76 |
分類號 | 415.837 |
關鍵詞 | Bladder cancer; Elderly; Radiation therapy; Concurrent chemoradiation; Bladder preservation; |
語文 | 英文(English) |
英文摘要 | Background: Bladder cancer is a disease frequently seen in the elderly. Frail and elderly patients with muscle-invasive bladder cancer (MIBC) are often unfit for surgery. While concurrent chemoradiotherapy (CCRT) is a well-established alternative treatment modality, only a small proportion of elderly patients receive CCRT. The purpose of this article is to review our experience with CCRT in elderly MIBC patients. Methods: Between January 1, 2007 and December 31, 2013, we retrospectively reviewed patients aged >75 who were treated with CCRT at Taipei Veterans General Hospital. Patients' characteristics, therapeutic strategy, clinical outcomes, and treatment-related toxicities were assessed. Results: Nineteen patients (4 females and 15 males) were identified. The median age was 79.5 years (range, 78.5e84.0 years) and the median follow-up was 33.7 months (interquartile range, 19.1e51.8 months). The major adverse event was grade 3 or grade 4 neutropenia, which developed in 10 of the 19 patients. No treatment-related mortality occurred. We found no association between prognosis and the chemotherapy regimen. Chemotherapy with a conventional dose of gemcitabine (800e1000 mg/m2 ) was well tolerated. The two-year and three-year estimated overall survival rates were 74% and 60%, respectively. Conclusion: CCRT after complete transurethral resection of the bladder tumor is feasible for elderly patients with MIBC. The conventional dose of gemcitabine as a chemosensitizer is adequate in the elderly population, but further investigation is needed. |
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