頁籤選單縮合
題名 | Differences in Risk Factors for Early-onset and Late-onset Biliary Complications in Liver Transplant Patients |
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作者姓名(外文) | Fan, Hsiu-lung; Feng, An-chieh; Ho, Meng-hsing; Kuo, Shih-ming; Chang, Wei-chou; Chen, Teng-wei; Chen, Teng-wei; Ho, Meng-hsing; Kuo, Shih-ming; Fan, Hsiu-lung; Feng, An-chieh; Chang, Wei-chou; | 書刊名 | Journal of Medical Sciences |
卷期 | 35:5 2015.10[民104.10] |
頁次 | 頁201-207 |
分類號 | 416.246 |
關鍵詞 | Acute rejection; Biliary complication; Liver transplantation; |
語文 | 英文(English) |
英文摘要 | Context: Despite the use of advanced surgical techniques, the incidence of biliary complications (BCs) after liver transplantation (LT) is high. Hence, there may be additional unidentified causes of BC. Aims: To identify the risk factors for BCs occurring within 6 months or beyond 6 months after LT. Materials and Methods: We enrolled 237 patients who underwent LT from August 2001 to December 2012. Of the 237 patients, 173 did not have BCs (no BC group), 42 had BCs within 6 months after LT (early-onset BC group), and 22 had BCs beyond 6 months after LT (late-onset BC group). Statistical Analysis Used: Patients' demographic, clinical, and biochemical data were analyzed using the Mann-Whitney U-test, Chi-square test, Fisher's exact test, and multiple logistic regression analysis. Results: Multivariate analysis indicated that only partial liver graft (odds ratio [OR], 2.741; 95% confidence interval [CI], 1.236-6.077; P=0.013) was an independent risk factor for early-onset BC after LT, whereas acute rejection (OR, 6.556; 95% CI, 2.380-18.056; P < 0.001), multiple bile ducts (OR, 4.227; 95% CI, 1.212-14.740; P=0.024), and pre-LT serum albumin level (OR, 2.234; 95% CI, 1.178-4.238; P=0.014) were the independent risk factors for late-onset BC after LT. Conclusion: Early-onset and late-onset BCs after LT are associated with different risk factors. Partial liver graft is a risk factor for early-onset BC, whereas pre-LT serum albumin level, multiple bile ducts, and acute rejection are the risk factors for late-onset BC. As it is easily controllable, prevention of acute rejection may help to reduce the incidence of BCs. |
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